Tracing the influence of caffeine on the pharmacokinetic parameters of three headache relieving pharmaceuticals applying synchronous fluorescence spectroscopy.

Autor:	Wahba MEK; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Delta University for Science and Technology, 35712, Gamasa, Egypt.; Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt., El Sherbiny D; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Delta University for Science and Technology, 35712, Gamasa, Egypt.; Department of Medicinal Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt., El Enany N; Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt.; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, New Mansoura University, PO Box 7723730, New Mansoura, Egypt., Draz ME; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Delta University for Science and Technology, 35712, Gamasa, Egypt.
Jazyk:	angličtina
Zdroj:	Methods and applications in fluorescence [Methods Appl Fluoresc] 2022 Aug 08; Vol. 10 (4). Date of Electronic Publication: 2022 Aug 08.
DOI:	10.1088/2050-6120/ac859a
Abstrakt:	A simple, sensitive, and selective first derivative synchronous fluorimetric method was developed and optimized to track the influence of caffeine content in beverages on the pharmacokinetic parameters of three pharmaceuticals used in relieving headache namely, aspirin (ASP), ibuprofen (IBU), and ergotamine tartrate (ERG). A full validation procedure was carried out to impart validity to the proposed method to apply it to biological fluids. The unique dissolving power of micellar solutions was utilized to avoid multiple extraction steps for both the in vitro and in vivo experiments, aiming to obtain acceptable recoveries and to accomplish sustainability, where 0.1 M sodium dodecyl sulphate (SDS) was used for this purpose. Moreover, the developed bioanalytical method was subjected to full validation to avoid interferences emerging from biological matrices. The greenness of the proposed method was assessed according to the Analytical Eco-Scale and proved to be excellent green carrying a score of 98%. (© 2022 IOP Publishing Ltd.)
Databáze:	MEDLINE
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