The effect of immunosuppression or thymectomy on the response to tetanus revaccination in myasthenia gravis.

Autor: Strijbos E; Department of Neurology, Leiden University Medical Centre, the Netherlands. Electronic address: e.strijbos@lumc.nl., van Ostaijen-Ten Dam MM; Department of Paediatrics, Laboratory of Immunology, Leiden University Medical Centre, the Netherlands., Vervat C; Department of Paediatrics, Laboratory of Immunology, Leiden University Medical Centre, the Netherlands., Schilham MW; Department of Paediatrics, Laboratory of Immunology, Leiden University Medical Centre, the Netherlands., Huijbers MGM; Department of Neurology, Leiden University Medical Centre, the Netherlands; Department of Human Genetics, Leiden University Medical Centre., van Tol MJD; Department of Paediatrics, Laboratory of Immunology, Leiden University Medical Centre, the Netherlands., Verschuuren JJGM; Department of Neurology, Leiden University Medical Centre, the Netherlands.
Jazyk: angličtina
Zdroj: Journal of neuroimmunology [J Neuroimmunol] 2022 Sep 15; Vol. 370, pp. 577930. Date of Electronic Publication: 2022 Jul 12.
DOI: 10.1016/j.jneuroim.2022.577930
Abstrakt: Objective: To determine the effect of tetanus toxoid (TT) revaccination on circulating B-, T- and NK-cell compartments in myasthenia gravis (MG) patients.
Methods: Lymphocyte (sub)populations and differentiation stages were assessed by flow cytometry in 50 TT revaccinated MG patients. TT-specific proliferative responses were explored in PBMC cultures.
Results: In patients treated with azathioprine B- and NK cell numbers were strongly decreased. Lymphocyte (sub)populations remained unaffected upon TT revaccination. t All patients showed a significant TT-induced proliferative response.
Conclusion: TT revaccination is effective in MG patients with stable disease irrespective of their thymectomy status and medication and does not alter the composition of the lymphocyte compartment.
(Copyright © 2022 The Authors. Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE