Effect of oral antiseptics on the viral load of SARS-CoV-2: A randomized controlled trial.

Autor:	Sevinç Gül SN; Department of Periodontology, Faculty of Dentistry, Atatürk University, Erzurum, Turkey., Dilsiz A; Department of Periodontology, Faculty of Dentistry, Atatürk University, Erzurum, Turkey., Sağlık İ; Department of Medical Microbiology, Faculty of Medicine, Bursa Uludağ University, Turkey., Aydın NN; Department of Infectious Diseases and Clinical Microbiology, Erzurum Regional Training and Research Hospital, Turkey.
Jazyk:	angličtina
Zdroj:	Dental and medical problems [Dent Med Probl] 2022 Jul-Sep; Vol. 59 (3), pp. 357-363.
DOI:	10.17219/dmp/150831
Abstrakt:	Background: In the oral cavity, which plays an important role in the transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), it is possible to reduce the viral load of SARS-CoV-2 with antiseptics, thereby minimizing the transmission of the virus during dental procedures. Objectives: The aim of this study was to clinically evaluate the effect of the hypochlorous acid (HClO) and povidone-iodine (PVP-I) solutions on the oral viral load of SARS-CoV-2. Material and Methods: This randomized controlled trial was conducted on 75 patients hospitalized in the COVID-19 ward of a local hospital. All the patients included in the study were within the first 24 h of hospitalization and the first 5 days of coronavirus disease 2019 (COVID-19) symptoms. The viral load of mouthwash samples was measured with the cycle threshold (Ct) value of SARS-CoV-2 through a realtime reverse transcription polymerase chain reaction (RT-PCR). The patients were divided into 3 groups. The effect on the patient's SARS-CoV-2 viral load was investigated after gargling the mouths and throats for 30 s with HClO, PVP-I and isotonic saline. First, a sample was taken after gargling with isotonic saline, then another sample was taken after gargling for 30 s with a particular antiseptic to determine the viral load of SARS-CoV-2. Results: Comparing the before and after mouthwash samples from all 3 groups, there were no statistically significant differences in the Ct values before and after gargling (p > 0.05). However, there were statistically significant differences in the number of negative samples after the use of HClO and PVP-I, which were positive before gargling (p < 0.05). Conclusions: In the light of the data obtained in this study, there is insufficient evidence that gargling with HClO or PVP-I reduces viral load. Taken together, these findings imply no role for antiseptics in the transmission of SARS-CoV-2 by the aerosol generated during dental procedures, or more generally, SARS-CoV-2 infection control.
Databáze:	MEDLINE
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