Effectiveness and safety of PRP on persistent olfactory dysfunction related to COVID-19.

Autor: Steffens Y; Department of Otorhinolaryngology, CHU Saint-Pierre, Rue aux Laines 105, 1000, Brussels, Belgium. younes.steffens@stpierre-bru.be., Le Bon SD; Department of Otorhinolaryngology, CHU Saint-Pierre, Rue aux Laines 105, 1000, Brussels, Belgium.; Department of Otorhinolaryngology, epiCURA, Mons, Belgium., Lechien J; Department of Otorhinolaryngology, CHU Saint-Pierre, Rue aux Laines 105, 1000, Brussels, Belgium., Prunier L; Department of Otorhinolaryngology, CHU Saint-Pierre, Rue aux Laines 105, 1000, Brussels, Belgium., Rodriguez A; Department of Otorhinolaryngology, CHU Saint-Pierre, Rue aux Laines 105, 1000, Brussels, Belgium., Saussez S; Department of Otorhinolaryngology, epiCURA, Mons, Belgium., Horoi M; Department of Otorhinolaryngology, CHU Saint-Pierre, Rue aux Laines 105, 1000, Brussels, Belgium.
Jazyk: angličtina
Zdroj: European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery [Eur Arch Otorhinolaryngol] 2022 Dec; Vol. 279 (12), pp. 5951-5953. Date of Electronic Publication: 2022 Jul 29.
DOI: 10.1007/s00405-022-07560-y
Abstrakt: Introduction: Olfactory dysfunction (OD) is a well know symptom of coronavirus disease 2019 (COVID-19), accounting for 48 to 85% of patients. In 1 to 10% of cases, patients develop a chronic olfactory dysfunction (COD), lasting more than 6 months. Recently, platelet-rich plasma (PRP) was used in patients with non-COVID-19 COD and authors reported encouraging results.
Methods: In the present study, we investigated the usefulness and safety of PRP injection in 56 patients with COVID-19 COD by the Sniffing Stick test (TDI score) and a linker-scale from 0 (none) to 3 (strong) and we compare the result to a control group.
Results: At 1 month post-PRP injection, the mean TDI scores significantly improved by 6.7 points in the PRP group (p < 0,001), the mean self-assessment of improvement in smell function was 1.8 (mild-to-moderate) in the PRP group, which was significantly higher than the score (0.3) in the control group (p < 0,001).
Conclusion: Our results showed that PRP in the olfactory cleft can increase the olfactory threshold 1 month after the injection. Moreover, our results suggest that timing of treatment may be an important factor and that PRP is a safe treatment, because no adverse effects were reported throughout the study.
Trial Registration Number: NCT05226546.
(© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
Databáze: MEDLINE
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