[Association of gene polymorphisms DRD3 rs6280, COMT rs4680 and HTR2A rs7322347 with schizophrenia].

Autor:	Sofronov AG; Mechnikov North-Western State Medical University, St. Petersburg, Russia.; Skvortsov-Stepanov St. Petersburg Psychiatric Hospital No 3, St. Petersburg, Russia., Dobrovolskaya AE; Mechnikov North-Western State Medical University, St. Petersburg, Russia.; Skvortsov-Stepanov St. Petersburg Psychiatric Hospital No 3, St. Petersburg, Russia., Morozova AY; Serbsky National Medical Research Center for Psychiatry and Narcology, Moscow, Russia.; Alexeev Mental-health Clinic No. 1 of Moscow, Moscow, Russia., Gorina EA; Skvortsov-Stepanov St. Petersburg Psychiatric Hospital No 3, St. Petersburg, Russia., Kolchev SA; Mechnikov North-Western State Medical University, St. Petersburg, Russia.; Skvortsov-Stepanov St. Petersburg Psychiatric Hospital No 3, St. Petersburg, Russia., Gvozdetckii AN; Mechnikov North-Western State Medical University, St. Petersburg, Russia.; Skvortsov-Stepanov St. Petersburg Psychiatric Hospital No 3, St. Petersburg, Russia.
Jazyk:	ruština
Zdroj:	Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova [Zh Nevrol Psikhiatr Im S S Korsakova] 2022; Vol. 122 (7), pp. 115-120.
DOI:	10.17116/jnevro2022122071115
Abstrakt:	Objective: To check the association of genetic polymorphisms rs6280 of the DRD3 gene, rs4680 of the COMT gene, rs7322347 of the HTR2A gene with schizophrenia. Material and Methods: The sample included 300 inpatients with paranoid schizophrenia. Inclusion criteria: age 18-50 years, established diagnosis «Schizophrenia, paranoid form», duration of psychiatric disorders not less than 5 years. The healthy control group consisted of 290 subjects. The association between polymorphisms and the study groups was assessed by logistic regression. Results: The CC genotype of the rs6280 polymorphism is associated with schizophrenia (OR 3.37 (1.50; 8.03)). The TT genotype of the rs7322347 polymorphism is associated with controls (OR 1.83 (1.25; 2.68)). Conclusion: These analyses confirmed the hypothesis that the genetic polymorphisms rs7322347 of the HTR2A gene ( p =0.006) and rs6280 of the DRD3 gene ( p =0.004) were associated with the disease. The hypothesis of an association of the rs4680 polymorphism of the COMT gene could not be confirmed.
Databáze:	MEDLINE
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