Comparison of Lapse Rate in Drug Dependent Patients in 2 Methods of Methadone Maintenance Treatment and Buprenorphine Maintenance Treatment.

Autor: Vafaeinasab M; Physical Medicine and Rehabilitation, Non-communicable Diseases Research Institue, Yazd Cardiovascular Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran., Zare H; General practitioner, Addiction Therapists Association, Fajr Addiction Treatment Center, Yazd, Iran., Dehghani A; Epidemiology, Department of Biostatistics and Epidemiology, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran., Malek S; Social Science, Addiction Therapists Association, Fajr Addiction Treatment Center, Yazd, Iran., Dehghani-Tafti M; Geriatric Nursing, Non-communicable Diseases Research Institue, Yazd Cardiovascular Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran., Sarebanhassanabadi M; Epidemiology, Non-communicable Diseases Research Institue, Yazd Cardiovascular Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Jazyk: angličtina
Zdroj: Substance abuse : research and treatment [Subst Abuse] 2022 Jul 22; Vol. 16, pp. 11782218221112502. Date of Electronic Publication: 2022 Jul 22 (Print Publication: 2022).
DOI: 10.1177/11782218221112502
Abstrakt: Background: Lapse has been one of the major challenges in the treatment of drug dependence sometimes leading to its relapse.
Objectives: The aim of this study was to determine the lapse rate in drug dependent patients as for the 2 methods of methadone maintenance treatment (MMT) and buprenorphine maintenance treatment (BMT) in Yazd city.
Methods: In this cross-sectional study, 626 female and male patients who had referred to 5 SUD treatment centers in Yazd and had been treated with methadone and buprenorphine maintenance were studied. Participants were divided into 2 groups of MMT and BMT and were evaluated based on lapse within 6 months.
Results: In this study, 60.9% of patients were treated with methadone but the rest were treated with buprenorphine. Overall, 33.1% of patients lapsed (35.2% for methadone and 29.8%for buprenorphine). Lapse in methadone treatment was correlated with age, occupational status, and duration of treatment ( P  < .05); it failed to correlated with any other demographic and clinical characteristics ( P  > .05). Lapse rate in buprenorphine treatment was also related to marital status and the drug used ( P  < .05). The mean dose of buprenorphine consumed showed no significant relationship with lapse ( P  > .05). The results demonstrated that given the low dose, lapse stood higher in the buprenorphine group than the methadone group; however, as to high dose, the buprenorphine group showed lower lapse than the other group.
Conclusions: In regard with the high rate of lapse, it is recommended to consider the factors related to the 2 methods of treatments, and provide counseling and training programs to lower lapse in the patients. Ethics Committee (REC) approval code: IR.SSU.REC.1394.158.
Competing Interests: Declaration of Conflicting Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
(© The Author(s) 2022.)
Databáze: MEDLINE
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