Cross-sectional Study of Workers Employed at a Copper Smelter-Effects of Long-term Exposures to Copper on Lung Function and Chronic Inflammation.

Autor:	Haase LM; From the Ramboll Deutschland GmbH, Essen, Germany (Ms Haase, Mr Birk); Regulatory Compliance Limited, Loanhead, Edinburgh (Dr Poland); Centre for Inflammation Research, University of Edinburgh, Edinburgh, UK (Dr Poland); Fraunhofer Institute for Toxicology and Experimental Medicine (ITEM), Hannover, Germany (Dr Holz, Dr Müller); German Center for Lung Research (DZL, BREATH), Hannover, Germany (Dr Holz); Ramboll US Consulting, Inc, Amherst, Massachusetts (Dr Bachand); Cardno ChemRisk, Boston, Massachusetts (Dr Mundt)., Birk T, Poland CA, Holz O, Müller M, Bachand AM, Mundt KA
Jazyk:	angličtina
Zdroj:	Journal of occupational and environmental medicine [J Occup Environ Med] 2022 Sep 01; Vol. 64 (9), pp. e550-e558. Date of Electronic Publication: 2022 Jul 28.
DOI:	10.1097/JOM.0000000000002610
Abstrakt:	Objective: The aim of the study was to assess the effect of exposure to copper-containing dust on lung function and inflammatory endpoints among workers of a German copper plant, effects rarely studied before. Methods: One hundred four copper-exposed smelter workers and 70 referent workers from the precious metal and lead facilities were included, with different metal exposures in both groups due to the different process materials. Body plethysmography, exhaled nitric oxide (FeNO) measurements, and blood sampling were conducted in all workers. Smoking status and the use of respiratory protective equipment were considered. In a subgroup of 40 nonsmoking volunteers (28 copper-exposed and 12 referents), sputum biomarkers were assessed. Results: Median lung function values of both copper-exposed and the referent groups were within reference ranges of "healthy" individuals, and statistical differences between the groups were mostly not evident. Similarly, differences in blood and sputum biomarkers were too small to be biologically relevant. Conclusion: The results suggest the absence of the detectable effects of copper-containing dust exposure on lung function or chronic inflammation within the investigated cohort. Competing Interests: Conflict of interest: The published work was part of a research project commissioned to the consultancy Ramboll by the International Copper Association (ICA). Dr Mundt supported Ramboll as independent consultant. The affiliated institutions of Dr Poland (University of Edinburgh), Dr Holz, and Dr Müller (Fraunhofer Institute for Toxicology and Experimental Medicine) received funding for their scientific input and contributions to the study from ICA as well. (Copyright © 2022 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American College of Occupational and Environmental Medicine.)
Databáze:	MEDLINE
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