[Acute leukemia in Fanconi's anemia. Report of a patient and review of the literature].

Autor: van Gils JE, Mandel C, van Weel-Sipman MH, de Koning J, van 't Veer-Korthof ET
Jazyk: Dutch; Flemish
Zdroj: Tijdschrift voor kindergeneeskunde [Tijdschr Kindergeneeskd] 1987 Apr; Vol. 55 (2), pp. 68-72.
Abstrakt: A case is reported of a 7 years old boy with Fanconi's Anemia (FA). The aplastic anemia has been treated with androgens. Six years after the confirmation of the diagnosis FA a (pre-)leukemia occurred. Because of the known complications of cytostatics in FA and the bad prognosis, the leukemia has not been treated. The boy died 4 months later. An overview of the literature shows 31 patients with acute non-lymphocytic leukemia in FA, of which the clinical course, chromosomal investigations and therapy are discussed.
Databáze: MEDLINE