Low muscle mass and mortality risk later in life: A 10-year follow-up study.

Autor: Camargo Pereira C; Postgraduate Program in Health Sciences, Medical School, Federal University of Goiás (UFG), Goiania, Brazil., Pagotto V; Faculty of Nursing, Postgraduate Program in Nursing, Federal University of Goiás (UFG), Goiania, Brazil., de Oliveira C; Department of Epidemiology & Public Health, University College London, London, United Kingdom., Silveira EA; Postgraduate Program in Health Sciences, Medical School, Federal University of Goiás (UFG), Goiania, Brazil.; Department of Epidemiology & Public Health, University College London, London, United Kingdom.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2022 Jul 28; Vol. 17 (7), pp. e0271579. Date of Electronic Publication: 2022 Jul 28 (Print Publication: 2022).
DOI: 10.1371/journal.pone.0271579
Abstrakt: Introduction: Little is known about the impact of low muscle mass (MM) assessed by calf circumference (CC), arm circumference (AC), arm muscle circumference (AMC), and corrected arm muscle circumference (CAMC)-on mortality risk later in life. We aimed to investigate the impact of low MM assessed by CC, AC, AMC and, CAMC on all-cause, cardiovascular, and cancer mortality risk.
Methods: Data came from 418 older adults who participated in a 10-year follow-up prospective cohort study. Low MM was defined as a CC < 33 cm for women and < 34 cm for men and by the lowest tertile of AC, AMC, and CAMC stratified by sex. The log rank test, Kaplan-Meier curves, and Cox regression were used.
Results: There were 147 deaths: 49 related to CVD and 22 to cancer. A small CC (HR = 1.57, 95% CI, 1.12-2.20), AMC (HR = 1.61, 95% CI, 1.13-2.30) and CAMC (HR = 1.45, 95% CI, 1.03-2.04) were associated with all-cause mortality. A small CAMC was a protective factor for CVD mortality (HR = 0.46, 95% CI, 0.22-0.98). In the Kaplan-Meier analysis, older adults with LMM presented low all-cause mortality survival, with AC (p < 0.05), AMC (p < 0.005), CAMC (p < 0.002), and CC (p < 0.001). Cancer mortality was associated with low CAMC (p < 0.020).
Conclusions: Low MM assessed by anthropometric measures (AC, AMC, CAMC and CC) increased the all-cause mortality risk. A small CAMC decreased the CVD mortality.
Competing Interests: The authors have declared that no competing interests exist.
Databáze: MEDLINE
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