Is paternal age associated with transfer day, developmental stage, morphology, and initial hCG-rise of the competent blastocyst leading to live birth? A multicenter cohort study.

Autor: Borgstrøm MB; Department of Obstetrics and Gynecology, The Fertility Clinic, Copenhagen University Hospital Herlev, Herlev, Denmark.; Aalborg University, Aalborg, Denmark., Grøndahl ML; Department of Obstetrics and Gynecology, The Fertility Clinic, Copenhagen University Hospital Herlev, Herlev, Denmark., W Klausen T; Department of Hematology, Copenhagen University Hospital Herlev, Herlev, Denmark., K Danielsen A; Department of Gastroenterology, Copenhagen University Hospital Herlev, Herlev, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark., Thomsen T; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.; Department of Anaesthesiology, Copenhagen University Hospital Herlev, Herlev, Denmark., Bentin-Ley U; Danish Fertility Clinic, The Fertility Partnership Denmark, Copenhagen, Denmark., B Knudsen U; The Fertility Clinic at Horsens regional hospital, Horsens, Deenmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Laursen S; The Fertility Clinic IVF-syd, Fredericia, Denmark., R Petersen M; Department of Obstetrics and Gynecology, The Fertility Clinic, Copenhagen University hospital, Rigshospitalet, Denmark., Haahr K; Stork IVF Clinic, Copenhagen, Denmark., Petersen K; VivaNeo Ciconia Fertility Clinic, Højbjerg, Denmark., Lemmen JG; Vitanova Fertility Center, København, Denmark., Hindkjær J; Aagaard Fertility Clinic, Aarhus, Denmark., Kirk J; Maigaard Fertility Clinic, Aarhus, Denmark., Fedder J; The Fertility Clinic, Odense University Hospital, Odense, Denmark., J Almind G; Copenhagen Fertility Center, Copenhagen, Denmark., Hnida C; The Fertility Clinic, Zealand University Hospital Køge, Køge, Denmark., Troest B; Aalborg University, Aalborg, Denmark.; The Fertility Unit, Aalborg University Hospital, Aalborg, Denmark., B Povlsen B; The Fertility Clinic, Skive Regional Hospital, Skive, Denmark., Zedeler A; Department of Obstetrics and Gynecology, The Fertility Clinic, Copenhagen University Hospital, Hvidovre, Denmark., Gabrielsen A; The Fertility Clinic at Horsens regional hospital, Horsens, Deenmark., Larsen T; Danish Medical Data Center, Copenhagen, Denmark., S Kesmodel U; Aalborg University, Aalborg, Denmark.; The Fertility Unit, Aalborg University Hospital, Aalborg, Denmark.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2022 Jul 28; Vol. 17 (7), pp. e0270664. Date of Electronic Publication: 2022 Jul 28 (Print Publication: 2022).
DOI: 10.1371/journal.pone.0270664
Abstrakt: In this study we investigated whether age of men undergoing assisted reproductive technology (ART) treatment was associated with day of transfer, stage, morphology, and initial hCG-rise of the competent blastocyst leading to a live birth? The design was a multicenter historical cohort study based on exposure (age) and outcome data (blastocyst stage and morphology and initial hCG-rise) from men whose partner underwent single blastocyst transfer resulting in singleton pregnancy/birth. The ART treatments were carried out at sixteen private and university-based public fertility clinics. We included 7246 men and women, who between 2014 and 2018 underwent controlled ovarian stimulation (COS) or Frozen-thawed Embryo Transfer (FET) with a single blastocyst transfer resulting in singleton pregnancy were identified. 4842 men with a partner giving birth were included, by linking data to the Danish Medical Birth Registry. We showed that the adjusted association between paternal age and transfer day in COS treatments was OR 1.06, 95% CI (1.00;1.13). Meaning that for every increase of one year, men had a 6% increased probability that the competent blastocyst was transferred on day 6 compared to day 5. Further we showed that the mean difference in hCG values when comparing paternal age group 30-34, 35-39 and 40-45 with the age group 25-29 in those receiving COS treatment, all showed significantly lower adjusted values for older men. In conclusion we hypothesize that the later transfer (day 6) in female partners of older men may be due to longer time spent by the oocyte to repair fragmented DNA of the sperm cells, which should be a focus of future research in men.
Competing Interests: I have read the journal’s policy and the authors of this manuscript have the following competing interests: [Dr. Grøndahl reports unrestricted grants from Gedeon Richter, Nordic, during the conduct of the study. DR. Schiøler Kesmodel reports personal fees from Merck, personal fees from IBSA Nordic, outside the submitted work.]
Databáze: MEDLINE
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