The impact of retinal fluid tolerance on the outcomes of neovascular age-related macular degeneration treated using aflibercept: A real-world study.

Autor: Jeng YT; Department of Ophthalmology, National Taiwan University Hospital, Taipei, Taiwan., Lai TT; Department of Ophthalmology, National Taiwan University Hospital, Taipei, Taiwan.; Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan., Lin CW; Department of Ophthalmology, National Taiwan University Hospital, Taipei, Taiwan., Chen TC; Department of Ophthalmology, National Taiwan University Hospital, Taipei, Taiwan., Hsieh YT; Department of Ophthalmology, National Taiwan University Hospital, Taipei, Taiwan., Lin CP; Department of Ophthalmology, National Taiwan University Hospital, Taipei, Taiwan., Ho TC; Department of Ophthalmology, National Taiwan University Hospital, Taipei, Taiwan., Yang CM; Department of Ophthalmology, National Taiwan University Hospital, Taipei, Taiwan.; Department of Ophthalmology, College of Medicine, National Taiwan University, Taipei, Taiwan., Yang CH; Department of Ophthalmology, National Taiwan University Hospital, Taipei, Taiwan.; Department of Ophthalmology, College of Medicine, National Taiwan University, Taipei, Taiwan.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2022 Jul 28; Vol. 17 (7), pp. e0271999. Date of Electronic Publication: 2022 Jul 28 (Print Publication: 2022).
DOI: 10.1371/journal.pone.0271999
Abstrakt: This study investigated the impact of retinal fluid tolerance on retinal thickness and visual acuity in patients with neovascular age-related macular degeneration after 18 months of treatment using intravitreal aflibercept. This retrospective study was based on the medical records of 90 eyes presenting persistent or recurrent retinal fluid retention after 3 months of aflibercept loading injections. We defined the fluid tolerance ratio as the sum of fluid-tolerance duration divided by the total duration of retinal fluid observed throughout the follow-up period. Eyes were categorized into strict, intermediate, and relaxed group based on their fluid tolerance ratio (= 0, <30%, > = 30%, respectively). The mean total follow-up time was 556 days. The relaxed group required fewer injections than the strict group (4.92 vs 7.50 injections, P < 0.01) and presented a similar reduction in retinal thickness (-57.50 vs -71.65 μm, P = 0.83). Nonetheless, the two groups were similar in terms of final visual acuity (logarithm of the minimum angle of resolution 0.72 vs 0.70, P = 0.95) and visual gains (4.21 vs -1.12 letters, P = 0.56). These results indicate that in the setting of limited medical resources, a fluid-tolerant approach provides comparable gains in visual acuity. Reducing the number of injections may also improve adherence to therapy.
Competing Interests: The authors have declared that no competing interests exist.
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje