Iron oxide nanoparticles coated with polydopamine as a potential nano-photothermal agent for treatment of melanoma cancer: an in vivo study.

Autor: Beigi FH; Falavarjan Branch, Islamic Azad University, Isfahan, Iran., Jazi SS; Department of Medical Physics, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran., Shahbazi-Gahrouei D; Department of Medical Physics, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran. shahbazi@med.mui.ac.ir., Khaniabadi PM; Department of Radiology and Molecular Imaging, College of Medicine and Health Science, Sultan Qaboos University, Al Khod, P.O. Box 35, Muscat 123, Oman., Hafezi H; Dermatology Department, Bandar Abbas University of Medical Sciences, Bandar Abbas, Iran., Monajemi R; Department of Biology, Falavarjan Azad University, Isfahan, Iran., Amiri GR; Falavarjan Branch, Islamic Azad University, Isfahan, Iran.
Jazyk: angličtina
Zdroj: Lasers in medical science [Lasers Med Sci] 2022 Dec; Vol. 37 (9), pp. 3413-3421. Date of Electronic Publication: 2022 Jul 28.
DOI: 10.1007/s10103-022-03599-9
Abstrakt: Melanoma is a metastatic cancer resistant to a wide range of therapies, including standard chemotherapy and radiation therapy, and cannot be treated with existing treatments owing to its intrinsic drug resistance. In terms of convenience and cheap cost of fabrication, one of the novel treatments is using polydopamine-coated iron oxide nanoparticles (IONs@PDA). Iron oxide nanoparticles (IONs) were synthesized (7.36 nm) and coated with polydopamine (15-20 nm). To examine the effect of photothermal ablation in melanoma cells (B16-F10), a Q-switched ruby laser (λ = 694 nm, spot size = 4 mm, output power = 5 J/s) was used. The prepared nanoprobe was applied to mice, and their survival after treatment was evaluated. Then histopathological studies were done on the livers and skins of the treated mice. The nanoparticles absorb the laser, raising the temperature and initiating photothermal treatment, with significant apoptosis (74%) after the 4th time of treatment. Photothermal therapy (PTT) by using IONs@PDA proved to be effective in the treatment of melanoma cells (tumor size of < 2 mm) without side effects. The lifespan of mice was significantly increased in a group of mice post-administered IONs@PDA and laser ablation. The fabricated nanoprobe (IONs@PDA) enhanced the melanoma cell apoptosis in the mice model, and it has promise for the treatment of melanoma (B16-F10) cells using photothermal therapy.
(© 2022. The Author(s), under exclusive licence to Springer-Verlag London Ltd., part of Springer Nature.)
Databáze: MEDLINE
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