Women with polycystic ovary syndrome have poorer work ability and higher disability retirement rate at midlife: a Northern Finland Birth Cohort 1966 study.

Autor:	Kujanpää L; PEDEGO Research Unit (Research Unit for Pediatrics, Dermatology, Clinical Genetics, Obstetrics and Gynecology), University of Oulu, Oulu, Finland.; Medical Research Center Oulu (MRC Oulu), University of Oulu, Oulu, Finland.; Department of Obstetrics and Gynecology, Oulu University Hospital, Oulu, Finland., Arffman RK; PEDEGO Research Unit (Research Unit for Pediatrics, Dermatology, Clinical Genetics, Obstetrics and Gynecology), University of Oulu, Oulu, Finland.; Medical Research Center Oulu (MRC Oulu), University of Oulu, Oulu, Finland.; Department of Obstetrics and Gynecology, Oulu University Hospital, Oulu, Finland., Vaaramo E; Infrastructure for Population Studies, Faculty of Medicine, University of Oulu, Oulu, Finland., Rossi HR; PEDEGO Research Unit (Research Unit for Pediatrics, Dermatology, Clinical Genetics, Obstetrics and Gynecology), University of Oulu, Oulu, Finland.; Medical Research Center Oulu (MRC Oulu), University of Oulu, Oulu, Finland.; Department of Obstetrics and Gynecology, Oulu University Hospital, Oulu, Finland., Laitinen J; Finnish Institute of Occupational Health, Oulu, Finland., Morin-Papunen L; PEDEGO Research Unit (Research Unit for Pediatrics, Dermatology, Clinical Genetics, Obstetrics and Gynecology), University of Oulu, Oulu, Finland.; Medical Research Center Oulu (MRC Oulu), University of Oulu, Oulu, Finland.; Department of Obstetrics and Gynecology, Oulu University Hospital, Oulu, Finland., Tapanainen J; PEDEGO Research Unit (Research Unit for Pediatrics, Dermatology, Clinical Genetics, Obstetrics and Gynecology), University of Oulu, Oulu, Finland.; Medical Research Center Oulu (MRC Oulu), University of Oulu, Oulu, Finland.; Department of Obstetrics and Gynecology, Oulu University Hospital, Oulu, Finland.; Department of Obstetrics and Gynecology, University of Helsinki, Helsinki University Hospital, Helsinki, Finland., Ala-Mursula L; Center for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland., Piltonen TT; PEDEGO Research Unit (Research Unit for Pediatrics, Dermatology, Clinical Genetics, Obstetrics and Gynecology), University of Oulu, Oulu, Finland.; Medical Research Center Oulu (MRC Oulu), University of Oulu, Oulu, Finland.; Department of Obstetrics and Gynecology, Oulu University Hospital, Oulu, Finland.
Jazyk:	angličtina
Zdroj:	European journal of endocrinology [Eur J Endocrinol] 2022 Aug 04; Vol. 187 (3), pp. 479-488. Date of Electronic Publication: 2022 Aug 04 (Print Publication: 2022).
DOI:	10.1530/EJE-22-0027
Abstrakt:	Objective: Polycystic ovary syndrome (PCOS) presents with multiple comorbidities potentially affecting function. This was the first general population-based study to evaluate work ability, participation in working life, and disability retirement in middle-aged women with and without PCOS. Design: This is a cohort study. Methods: Women with PCOS (n = 280) and women without PCOS symptoms or diagnosis (n = 1573) were identified in the Northern Finland Birth Cohort in 1966 and were evaluated for self-rated work ability and potential confounders at age 46. Next, incidence rate ratios (IRRs) for disability and unemployment days were extracted from national registers during a prospective 2-year follow-up. Lastly, we assessed hazard ratios (HRs) for disability retirement between 16 and 52 years of age from national registers. Results: The women with PCOS reported poorer ability to work at age 46, especially due to poorer health. During the 2-year follow-up period, the affected women gained on average an additional month of disability and unemployment days, corresponding to an approximately 25% higher risk for both disability (IRR (95% CI): 1.25 (1.22-1.27)) and unemployment days (IRR (95% CI): 1.26 (1.23-1.28)) in models adjusted for health and socioeconomic factors. Lastly, we found a two-fold higher cumulative risk for disability retirement by age 52 compared to non-PCOS women (HR (95% CI): 1.98 (1.40-2.80)), which remained after adjusting for confounding factors (aHR (95% CI): 1.55 (1.01-2.38)). Conclusions: PCOS is associated with lower participation in working life already in midlife. Acknowledging PCOS-related multimorbidity, concerted efforts are needed to support sustainable careers for women with PCOS.
Databáze:	MEDLINE
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