SARS-CoV-2 genomic epidemiology: data and sequencing infrastructure.

Autor:	Merhi G; Department of Natural Sciences, School of Arts & Sciences, Lebanese American University, Byblos, Lebanon., Koweyes J; Department of Natural Sciences, School of Arts & Sciences, Lebanese American University, Byblos, Lebanon., Salloum T; Department of Natural Sciences, School of Arts & Sciences, Lebanese American University, Byblos, Lebanon., Khoury CA; Department of Natural Sciences, School of Arts & Sciences, Lebanese American University, Byblos, Lebanon., Haidar S; Department of Natural Sciences, School of Arts & Sciences, Lebanese American University, Byblos, Lebanon., Tokajian S; Department of Natural Sciences, School of Arts & Sciences, Lebanese American University, Byblos, Lebanon.
Jazyk:	angličtina
Zdroj:	Future microbiology [Future Microbiol] 2022 Sep; Vol. 17, pp. 1001-1007. Date of Electronic Publication: 2022 Jul 28.
DOI:	10.2217/fmb-2021-0207
Abstrakt:	Background: Genomic surveillance of SARS-CoV-2 is critical in monitoring viral lineages. Available data reveal a significant gap between low- and middle-income countries and the rest of the world. Methods: The SARS-CoV-2 sequencing costs using the Oxford Nanopore MinION device and hardware prices for data computation in Lebanon were estimated and compared with those in developed countries. SARS-CoV-2 genomes deposited on the Global Initiative on Sharing All Influenza Data per 1000 COVID-19 cases were determined per country. Results: Sequencing costs in Lebanon were significantly higher compared with those in developed countries. Low- and middle-income countries showed limited sequencing capabilities linked to the lack of support, high prices, long delivery delays and limited availability of trained personnel. Conclusion: The authors recommend the mobilization of funds to develop whole-genome sequencing-based surveillance platforms and the implementation of genomic epidemiology to better identify and track outbreaks, leading to appropriate and mindful interventions.
Databáze:	MEDLINE
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