Case Report: Primary Leptomeningeal Medulloblastoma in a Child: Clinical Case Report and Literature Review.

Autor:	Morgacheva D; Almazov National Medical Research Centre, Saint Petersburg, Russia., Daks A; Almazov National Medical Research Centre, Saint Petersburg, Russia.; Laboratory of Gene Expression Regulation, Institute of Cytology, Russian Academy of Sciences, Saint Petersburg, Russia., Smirnova A; Almazov National Medical Research Centre, Saint Petersburg, Russia., Kim A; Almazov National Medical Research Centre, Saint Petersburg, Russia., Ryzhkova D; Almazov National Medical Research Centre, Saint Petersburg, Russia., Mitrofanova L; Almazov National Medical Research Centre, Saint Petersburg, Russia., Staliarova A; Hematology and Immunology, Oncological Department 3, Belarusian Research Center for Pediatric Oncology, Minsk, Belarus., Omelina E; Laboratory of Cell Division, Department of Regulation of Genetic Processes, Institute of Molecular and Cellular Biology, Siberian Branch of Russian Academy of Sciences, Novosibirsk, Russia., Pindyurin A; Laboratory of Cell Division, Department of Regulation of Genetic Processes, Institute of Molecular and Cellular Biology, Siberian Branch of Russian Academy of Sciences, Novosibirsk, Russia., Fedorova O; Almazov National Medical Research Centre, Saint Petersburg, Russia.; Laboratory of Gene Expression Regulation, Institute of Cytology, Russian Academy of Sciences, Saint Petersburg, Russia., Shuvalov O; Almazov National Medical Research Centre, Saint Petersburg, Russia.; Laboratory of Gene Expression Regulation, Institute of Cytology, Russian Academy of Sciences, Saint Petersburg, Russia., Petukhov A; Almazov National Medical Research Centre, Saint Petersburg, Russia.; Laboratory of Gene Expression Regulation, Institute of Cytology, Russian Academy of Sciences, Saint Petersburg, Russia., Dinikina Y; Almazov National Medical Research Centre, Saint Petersburg, Russia.
Jazyk:	angličtina
Zdroj:	Frontiers in pediatrics [Front Pediatr] 2022 Jul 11; Vol. 10, pp. 925340. Date of Electronic Publication: 2022 Jul 11 (Print Publication: 2022).
DOI:	10.3389/fped.2022.925340
Abstrakt:	Medulloblastoma is one of the most common pediatric central nervous system malignancies worldwide, and it is characterized by frequent leptomeningeal metastasizing. We report a rare case of primary leptomeningeal medulloblastoma of an 11-year-old Caucasian girl with a long-term disease history, non-specific clinical course, and challenges in the diagnosis verification. To date, 4 cases of pediatric primary leptomeningeal medulloblastoma are reported, and all of them are associated with unfavorable outcomes. The approaches of neuroimaging and diagnosis verification are analyzed in the article to provide opportunities for effective diagnosis of this disease in clinical practice. The reported clinical case of the primary leptomeningeal medulloblastoma is characterized by MR images with non-specific changes in the brain and spinal cord and by 18FDG-PET/CT images with diffuse heterogeneous hyperfixation of the radiopharmaceutical along the whole spinal cord. The immunohistochemistry and next-generation sequencing analyses of tumor samples were performed for comprehensive characterization of the reported clinical case. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Morgacheva, Daks, Smirnova, Kim, Ryzhkova, Mitrofanova, Staliarova, Omelina, Pindyurin, Fedorova, Shuvalov, Petukhov and Dinikina.)
Databáze:	MEDLINE
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