Potassium Channels as a Target for Cancer Therapy: Current Perspectives.

Autor: Zúñiga L; Laboratorio de Fisiología Molecular, Escuela de Medicina, Universidad de Talca, Talca, Chile.; Centro de Nanomedicina, Diagnóstico y Desarrollo de Fármacos (ND3), Escuela de Medicina, Universidad de Talca, Talca, Chile., Cayo A; Laboratorio de Fisiología Molecular, Escuela de Medicina, Universidad de Talca, Talca, Chile.; Centro de Nanomedicina, Diagnóstico y Desarrollo de Fármacos (ND3), Escuela de Medicina, Universidad de Talca, Talca, Chile., González W; Centro de Bioinformática y Simulación Molecular, Universidad de Talca, Talca, Chile.; Millennium Nucleus of Ion Channels-Associated Diseases (MiNICAD), Universidad de Talca, Talca, Chile., Vilos C; Centro de Nanomedicina, Diagnóstico y Desarrollo de Fármacos (ND3), Escuela de Medicina, Universidad de Talca, Talca, Chile.; Laboratory of Nanomedicine and Targeted Delivery, School of Medicine, Universidad de Talca, Talca, 3460000, Chile.; Center for The Development of Nanoscience & Nanotechnology (CEDENNA), Universidad de Santiago de Chile, Santiago, 8350709, Chile., Zúñiga R; Laboratorio de Fisiología Molecular, Escuela de Medicina, Universidad de Talca, Talca, Chile.; Centro de Nanomedicina, Diagnóstico y Desarrollo de Fármacos (ND3), Escuela de Medicina, Universidad de Talca, Talca, Chile.
Jazyk: angličtina
Zdroj: OncoTargets and therapy [Onco Targets Ther] 2022 Jul 20; Vol. 15, pp. 783-797. Date of Electronic Publication: 2022 Jul 20 (Print Publication: 2022).
DOI: 10.2147/OTT.S326614
Abstrakt: Potassium (K + ) channels are highly regulated membrane proteins that control the potassium ion flux and respond to different cellular stimuli. These ion channels are grouped into three major families, Kv (voltage-gated K + channel), Kir (inwardly rectifying K + channel) and K2P (two-pore K + channels), according to the structure, to mediate the K + currents. In cancer, alterations in K + channel function can promote the acquisition of the so-called hallmarks of cancer - cell proliferation, resistance to apoptosis, metabolic changes, angiogenesis, and migratory capabilities - emerging as targets for the development of new therapeutic drugs. In this review, we focus our attention on the different K + channels associated with the most relevant and prevalent cancer types. We summarize our knowledge about the potassium channels structure and function, their cancer dysregulated expression and discuss the K + channels modulator and the strategies for designing new drugs.
Competing Interests: The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed in the funding section and report no conflicts of interest in relation to this work.
(© 2022 Zúñiga et al.)
Databáze: MEDLINE
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