[Status Of Markers Of Oxidative Stress At The Internal Medicine And Endocrinology Department Of The Mali Hospital].

Autor: Sow DS; Service de médecine interne et d'endocrinologie de l'hôpital du Mali., Traoré D; Service de médecine interne du CHU du Point G., Dramé B; Service de biologie médicale de l'hôpital du Mali., Konaté M; Service de médecine interne et d'endocrinologie de l'hôpital du Mali., Bah M; Service de médecine interne et d'endocrinologie de l'hôpital du Mali., Gninkoun CJ; Service de médecine interne et d'endocrinologie de l'hôpital du Mali., Traoré B; Service de médecine interne et d'endocrinologie de l'hôpital du Mali., Mariko M; Service de médecine interne et d'endocrinologie de l'hôpital du Mali., Traoré AK; Service de médecine interne du CHU du Point G., Sidibé AT; Service de médecine interne et d'endocrinologie de l'hôpital du Mali.
Jazyk: francouzština
Zdroj: Le Mali medical [Mali Med] 2019; Vol. 34 (2), pp. 45-51.
Abstrakt: Oxidative stress represents an imbalance between the endogenous antioxidant defenses and the production of pro-oxidant molecules. The present study describes oxidative stress markers (oxidant and antioxidant) metabolic disturbances in diabetic and non-diabetic patients at the Internal Medicine and Endocrinology ward of hospital of Mali.
Materials and Methods: We conducted a descriptive case / control study involving 30 diabetic and 30 non-diabetic patients. Studied markers were Glutathione erythrocyte peroxidase (GPX), intra erythrocyte Superoxide dismutase (SOD), plasmatic uric acid, direct and total bilirubins, albumin and markers for diagnosis and monitoring of diabetes.
Results: Non-diabetic patients (9%) had higher glutathione peroxidase levels compared diabetics (3%) (p = 0.005). An increase in superoxide dismutase was observed in 73.3% of diabetics versus 40% of nondiabetics (p = 0). The albumin, uric acid and bilirubin levels were identical in both populations. Glycated hemoglobin was significantly correlated with microangiopathies (p = 0.0058) and macro angiopathies( p=0,0007) in diabetics.
Conclusion: The study showed an increase in antioxidant defenses in diabetics by the elevation of superoxide dismutase and a relative normalization of glutathione peroxidase.
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Databáze: MEDLINE
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