Dairying, diseases and the evolution of lactase persistence in Europe.

Autor: Evershed RP; Organic Geochemistry Unit, School of Chemistry, University of Bristol, Bristol, UK. R.P.Evershed@bristol.ac.uk., Davey Smith G; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK. KZ.Davey-Smith@bristol.ac.uk.; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK. KZ.Davey-Smith@bristol.ac.uk.; NIHR Bristol Biomedical Research Centre, University of Bristol, Bristol, UK. KZ.Davey-Smith@bristol.ac.uk., Roffet-Salque M; Organic Geochemistry Unit, School of Chemistry, University of Bristol, Bristol, UK. melanie.salque@bristol.ac.uk., Timpson A; Department of Genetics, Evolution and Environment, University College London, London, UK.; Max Planck Institute for the Science of Human History, Jena, Germany., Diekmann Y; Department of Genetics, Evolution and Environment, University College London, London, UK.; Palaeogenetics Group, Institute of Organismic and Molecular Evolution (iomE), Johannes Gutenberg University Mainz, Mainz, Germany., Lyon MS; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.; NIHR Bristol Biomedical Research Centre, University of Bristol, Bristol, UK., Cramp LJE; Department of Anthropology and Archaeology, University of Bristol, Bristol, UK., Casanova E; Organic Geochemistry Unit, School of Chemistry, University of Bristol, Bristol, UK., Smyth J; Organic Geochemistry Unit, School of Chemistry, University of Bristol, Bristol, UK.; School of Archaeology, University College Dublin, Dublin, Ireland., Whelton HL; Organic Geochemistry Unit, School of Chemistry, University of Bristol, Bristol, UK., Dunne J; Organic Geochemistry Unit, School of Chemistry, University of Bristol, Bristol, UK., Brychova V; Department of Dairy, Fat and Cosmetics, University of Chemistry and Technology Prague, Prague, Czech Republic.; Nuclear Dosimetry Department, Institute of Nuclear Physics of the Czech Academy of Sciences, Prague, Czech Republic., Šoberl L; Organic Geochemistry Unit, School of Chemistry, University of Bristol, Bristol, UK., Gerbault P; Department of Genetics, Evolution and Environment, University College London, London, UK.; School of Life Sciences, University of Westminster, London, UK., Gillis RE; Archéozoologie, Archéobotanique: Sociétés, Pratiques et Environnement (UMR 7209), CNRS-Muséum National d'Histoire Naturelle-Sorbonne Universités, Paris, France.; ICArEHB, Faculdade de Ciências Humanas e Sociais, Universidade do Algarve, Faro, Portugal., Heyd V; Department of Anthropology and Archaeology, University of Bristol, Bristol, UK.; Department of Cultures, Section of Archaeology, University of Helsinki, Helsinki, Finland., Johnson E; Department of Archaeology, University of Exeter, Exeter, UK.; Archaeology South-East, UCL Institute of Archaeology, University College London, London, UK., Kendall I; Organic Geochemistry Unit, School of Chemistry, University of Bristol, Bristol, UK., Manning K; Department of Geography, King's College London, London, UK., Marciniak A; Institute of Prehistory, Adam Mickiewicz University, Poznań, Poland., Outram AK; Department of Archaeology, University of Exeter, Exeter, UK., Vigne JD; Archéozoologie, Archéobotanique: Sociétés, Pratiques et Environnement (UMR 7209), CNRS-Muséum National d'Histoire Naturelle-Sorbonne Universités, Paris, France., Shennan S; UCL Institute of Archaeology, University College London, London, UK., Bevan A; UCL Institute of Archaeology, University College London, London, UK., Colledge S; UCL Institute of Archaeology, University College London, London, UK., Allason-Jones L; Great North Museum (former Museum of Antiquities), Newcastle, UK., Amkreutz L; National Museum of Antiquities, Leiden, the Netherlands., Anders A; Institute of Archaeological Sciences, Eötvös Loránd University, Budapest, Hungary., Arbogast RM; UMR 7044, ARCHIMEDE, University of Strasbourg, Strasbourg, France., Bălăşescu A; Department of Bioarchaeology, 'Vasile Pârvan' Institute of Archaeology, Romanian Academy, Bucharest, Romania., Bánffy E; Institute of Archaeology, Research Centre for the Humanities, Eötvös Loránd Research Network, Centre of Excellence of the Hungarian Academy of Sciences, Budapest, Hungary.; Römisch-Germanische Kommission, Frankfurt, Germany., Barclay A; Cotswold Archaeology, Cirencester, UK., Behrens A; German Archaeological Institute, Berlin, Germany., Bogucki P; School of Engineering and Applied Science, Princeton University, Princeton, NJ, USA., Carrancho Alonso Á; Área de Prehistoria, Departamento de Historia, Geografía y Comunicación, University of Burgos, Burgos, Spain., Carretero JM; Laboratorio Evolución Humana, University of Burgos, Burgos, Spain.; Centro Mixto UCM-ISCIII de Evolución y Comportamiento Humana, Madrid, Spain., Cavanagh N; Network Archaeology, Lincoln, UK., Claßen E; LVR-State Service for Archaeological Heritage, Bonn, Germany., Collado Giraldo H; Patrimonio & Arte Research Group, Extremadura University, Badajoz and Cáceres, Badajoz, Spain.; Geosciences Centre, Coimbra University, Coimbra, Portugal., Conrad M; Landesamt für Archaeologie, Dresden, Germany., Csengeri P; Herman Ottó Museum, Miskolc, Hungary., Czerniak L; Institute of Archaeology and Ethnology, University of Gdańsk, Gdańsk, Poland., Dębiec M; Institute of Archaeology, University Rzeszów, Rzeszów, Poland., Denaire A; UMR 6298, ARTEHIS, University of Burgundy, Dijon, France., Domboróczki L; Dobó István Castle Museum, Eger, Hungary., Donald C; The McManus: Dundee's Art Gallery & Museum, Dundee, UK., Ebert J; Institute of Prehistoric Archaeology, Free University of Berlin, Berlin, Germany., Evans C; Cambridge Archaeological Unit, University of Cambridge, Cambridge, UK., Francés-Negro M; Laboratorio Evolución Humana, University of Burgos, Burgos, Spain., Gronenborn D; Römisch-Germanisches Zentralmuseum, Leibniz Research Institute for Archaeology, Mainz, Germany., Haack F; Archaeological Department, Landesmuseum Württemberg, Stuttgart, Germany., Halle M; Landesamt für Archaeologie, Dresden, Germany., Hamon C; UMR 8215, Trajectoires, Université Paris 1 Panthéon-Sorbonne, Paris, France., Hülshoff R; State Office for Heritage Management and Archaeology, Saxony Anhalt/State Museum of Prehistory, Halle/Saale, Germany., Ilett M; UMR 8215, Trajectoires, Université Paris 1 Panthéon-Sorbonne, Paris, France., Iriarte E; Laboratorio Evolución Humana, University of Burgos, Burgos, Spain., Jakucs J; Institute of Archaeology, Research Centre for the Humanities, Eötvös Loránd Research Network, Centre of Excellence of the Hungarian Academy of Sciences, Budapest, Hungary., Jeunesse C; UMR 7044, ARCHIMEDE, University of Strasbourg, Strasbourg, France., Johnson M; CFA Archaeology, Musselburgh, UK., Jones AM; Cornwall Archaeological Unit, Cornwall Council, Truro, UK., Karul N; Istanbul University, Istanbul, Turkey., Kiosak D; 'I.I. Mechnikov', Odessa National University, Odessa, Ukraine.; Ca' Foscari, University of Venice, Venice, Italy., Kotova N; Institute of Archaeology of Academy of Science of Ukraine, Kiev, Ukraine., Krause R; Prehistory Department, Institut of Archaeology, Johann Wolfgang Goethe-Universität, Frankfurt, Germany., Kretschmer S; Landesamt für Archaeologie, Dresden, Germany., Krüger M; Department of Archaeology, Adam Mickiewicz University, Poznań, Poland., Lefranc P; UMR 7044, INRAP Grand-Est Sud, University of Strasbourg, Strasbourg, France., Lelong O; GUARD Glasgow, Glasgow, UK.; Eunomia Research & Consulting, Bristol, UK., Lenneis E; Department of Prehistoric and Historical Archaeology, University of Vienna, Vienna, Austria., Logvin A; Kostanay State University, Kostanay, Kazakhstan., Lüth F; German Archaeological Institute, Berlin, Germany., Marton T; Institute of Archaeology, Research Centre for the Humanities, Eötvös Loránd Research Network, Centre of Excellence of the Hungarian Academy of Sciences, Budapest, Hungary., Marley J; Royal Cornwall Museum, Truro, UK., Mortimer R; Oxford Archaeology East, Oxford, UK., Oosterbeek L; Geosciences Centre, Coimbra University, Coimbra, Portugal.; Polytechnic Institute of Tomar, Tomar, Portugal.; Terra e Memória Institute, Mação, Portugal., Oross K; Institute of Archaeology, Research Centre for the Humanities, Eötvös Loránd Research Network, Centre of Excellence of the Hungarian Academy of Sciences, Budapest, Hungary., Pavúk J; Archeologický ústav SAV, Nitra, Slovakia., Pechtl J; Kelten Römer Museum Manching, Manching, Germany.; Department of Archaeology, University of Innsbruck, Innsbruck, Austria., Pétrequin P; MSHE C.N. Ledoux, CNRS & University of Franche-Comté, Besançon, France., Pollard J; Department of Archaeology, University of Southampton, Southampton, UK., Pollard R; Leicestershire County Council Museums, Leicestershire, UK., Powlesland D; The Landscape Research Centre Ltd., West Heslerton, UK., Pyzel J; Institute of Archaeology and Ethnology, University of Gdańsk, Gdańsk, Poland., Raczky P; Institute of Archaeological Sciences, Eötvös Loránd University, Budapest, Hungary., Richardson A; Canterbury Archaeological Trust, Canterbury, UK., Rowe P; Tees Archaeology, Hartlepool, UK.; North Yorkshire County Council HER, Northallerton, UK., Rowland S; Oxford Archaeology North, Lancaster, UK., Rowlandson I; Archaeological Consultancy, Emsworth, UK., Saile T; Institute of History, University of Regensburg, Regensburg, Germany., Sebők K; Institute of Archaeological Sciences, Eötvös Loránd University, Budapest, Hungary., Schier W; Institute of Prehistoric Archaeology, Free University of Berlin, Berlin, Germany., Schmalfuß G; Landesamt für Archaeologie, Dresden, Germany., Sharapova S; Institute of History and Archaeology, UB RAS, Ekaterinburg, Russia., Sharp H; Leicestershire County Council Museums, Leicestershire, UK., Sheridan A; National Museums Scotland, Edinburgh, UK., Shevnina I; Kostanay State University, Kostanay, Kazakhstan., Sobkowiak-Tabaka I; Institute of Archaeology and Ethnology, Polish Academy of Sciences, Poznań, Poland.; Faculty of Archaeology, Adam Mickiewicz University, Poznań, Poland., Stadler P; Department of Prehistoric and Historical Archaeology, University of Vienna, Vienna, Austria., Stäuble H; Landesamt für Archaeologie, Dresden, Germany., Stobbe A; Prehistory Department, Institut of Archaeology, Johann Wolfgang Goethe-Universität, Frankfurt, Germany., Stojanovski D; Geology Department, University of Trás-os-Montes and Alto Douro, Vila Real, Portugal.; Department of Humanistic Studies, University of Ferrara, Ferrara, Italy., Tasić N; University of Belgrade, Belgrad, Serbia., van Wijk I; Faculty of Archaeology, Leiden University, Leiden, the Netherlands., Vostrovská I; Institute of Archaeology and Museology, Masaryk University, Brno, Czech Republic.; Department of History, Palacký University, Olomouc, Czech Republic., Vuković J; University of Belgrade, Belgrad, Serbia., Wolfram S; Staatliches Museum für Archäologie, Chemnitz, Germany., Zeeb-Lanz A; Generaldirektion Kulturelles Erbe Rheinland-Pfalz, Dir. Landesarchäologie, Speyer, Germany., Thomas MG; Department of Genetics, Evolution and Environment, University College London, London, UK. m.thomas@ucl.ac.uk.; UCL Genetics Institute, University College London, London, UK. m.thomas@ucl.ac.uk.
Jazyk: angličtina
Zdroj: Nature [Nature] 2022 Aug; Vol. 608 (7922), pp. 336-345. Date of Electronic Publication: 2022 Jul 27.
DOI: 10.1038/s41586-022-05010-7
Abstrakt: In European and many African, Middle Eastern and southern Asian populations, lactase persistence (LP) is the most strongly selected monogenic trait to have evolved over the past 10,000 years 1 . Although the selection of LP and the consumption of prehistoric milk must be linked, considerable uncertainty remains concerning their spatiotemporal configuration and specific interactions 2,3 . Here we provide detailed distributions of milk exploitation across Europe over the past 9,000 years using around 7,000 pottery fat residues from more than 550 archaeological sites. European milk use was widespread from the Neolithic period onwards but varied spatially and temporally in intensity. Notably, LP selection varying with levels of prehistoric milk exploitation is no better at explaining LP allele frequency trajectories than uniform selection since the Neolithic period. In the UK Biobank 4,5 cohort of 500,000 contemporary Europeans, LP genotype was only weakly associated with milk consumption and did not show consistent associations with improved fitness or health indicators. This suggests that other reasons for the beneficial effects of LP should be considered for its rapid frequency increase. We propose that lactase non-persistent individuals consumed milk when it became available but, under conditions of famine and/or increased pathogen exposure, this was disadvantageous, driving LP selection in prehistoric Europe. Comparison of model likelihoods indicates that population fluctuations, settlement density and wild animal exploitation-proxies for these drivers-provide better explanations of LP selection than the extent of milk exploitation. These findings offer new perspectives on prehistoric milk exploitation and LP evolution.
(© 2022. The Author(s), under exclusive licence to Springer Nature Limited.)
Databáze: MEDLINE
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