| Autor: |
Sugeçti S; Department of Veterinary Medicine, Çaycuma Food and Agriculture Vocational School, Zonguldak Bülent Ecevit University, Zonguldak, Turkey., Tunçsoy B; Faculty of Engineering, Department of Bioengineering, Adana Alparslan Turkeş Science and Technology University, Adana, Turkey., Büyükgüzel E; Science and Art Faculty, Department of Molecular Biology and Genetics, Zonguldak Bülent Ecevit University, Zonguldak, Turkey., Özalp P; Science and Art Faculty Department of Biology, Çukurova University, Adana, Turkey., Büyükgüzel K; Science and Art Faculty, Department of Biology, Zonguldak Bülent Ecevit University, Zonguldak, Turkey. |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of environmental science and health. Part C, Toxicology and carcinogenesis [J Environ Sci Health C Toxicol Carcinog] 2021; Vol. 39 (4), pp. 423-434. Date of Electronic Publication: 2021 Sep 09. |
| DOI: |
10.1080/26896583.2021.1969846 |
| Abstrakt: |
Nanoparticles (NPs) are now being used in many industrial activities, such as mining, paint and glass industries. The frequent industrial use of NPs contributes to environmental pollution and may cause cellular and oxidative damage in native organisms. In this study, the toxic effects of titanium dioxide nanoparticles (TiO 2 NPs) were investigated using Galleria mellonella larvae as a model insect species. Alterations in cell damage indicators, such as alanine transferase, aspartate transferase, lactate dehydrogenase, non-enzymatic antioxidants and biochemical parameters, were determined in the hemolymph of G. mellonella larvae exposed to TiO 2 NPs at different concentrations (5, 50, 250 and 1250 μg/mL) in their diets. TiO 2 NPs caused concentration-dependent cellular damage in the hemolymph of G. mellonella larvae and increased the levels of the non-enzymatic antioxidants uric acid and bilirubin. In addition, total protein in hemolymph significantly decreased at the highest concentration (1250 μg/mL) of TiO 2 NPs. Level of the urea increased at the highest concentration (1250 μg/mL) of TiO 2 NPs, whereas the amount of glucose was not affected. These findings demonstrated that TiO 2 NPs caused concentration-dependent toxic effects on G. mellonella larvae. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
