| Autor: |
Brennan E; School of Medicine, Royal College of Surgeons in Ireland-Medical University of Bahrain, Busaiteen, Bahrain., Kumar N; School of Medicine, Royal College of Surgeons in Ireland-Medical University of Bahrain, Busaiteen, Bahrain., Drage DS; School of Geography, Earth and Environmental Sciences, University of Birmingham, UK.; Queensland Alliance for Environmental Health Sciences, The University of Queensland, Qld, Australia., Cunningham TK; Obstetrics and Gynaecology, Hull Royal Infirmary, Hull, England, UK., Sathyapalan T; Academic Endocrinology, Diabetes and Metabolism, Hull York Medical School, University of Hull, UK., Mueller JF; Queensland Alliance for Environmental Health Sciences, The University of Queensland, Qld, Australia., Atkin SL; School of Postgraduate Studies and Research, Royal College of Surgeons in Ireland-Medical University of Bahrain, Busaiteen, Bahrain. |
| Abstrakt: |
Polychlorinated biphenyls (PCBs) are a class of environmental pollutants with a long half-life that sequester in fat. Women with polycystic ovarian syndrome (PCOS) may represent a sensitive subgroup to endogenous exposure to PCBs because of associated weight gain. Seven PCB congeners were compared in age, ethnicity, and BMI matched women with ( n = 29) and without ( n = 30) PCOS and related to metabolic outcomes, and steroid and thyroid hormone levels. PCB118, PCB138, PCB153, and PCB180 were detected in all serum samples but geometric mean did not differ between cases and controls. PCBs correlated with increasing concentrations of each other ( p < .01), increasing age ( p < .01) and decreasing lneGFR ( p < .05). lnPCB118 correlated with increasing Free-T4 ( p = .028). lnPCB158, lnPCB180, and ln∑PCB correlated with increasing lnSHBG ( p = .044). In regression modeling, although not significant, PCB118 positively associated with lnSHBG in controls ( p = .0504) but not in cases; estradiol inversely associated with PCB138 in controls ( p = .055) and ∑PCB in cases ( p = .051). No significant associations were observed between metabolic endpoints, and steroid and thyroid hormone levels. The results presented do not suggest the PCOS cases in this cohort are at adverse risk compared to age, ethnicity, and BMI matched controls. |
