| Autor: |
Hammond MM; Northwestern University Feinberg School of Medicine Chicago IL., Spring B; Northwestern University Feinberg School of Medicine Chicago IL., Rejeski WJ; Departments of Health and Exercise Science and Geriatric Medicine Wake Forest University Winston Salem NC., Sufit R; Northwestern University Feinberg School of Medicine Chicago IL., Criqui MH; University of California at San Diego San Diego CA., Tian L; Department of Biomedical Data Science Stanford University Palo Alto CA., Zhao L; Northwestern University Feinberg School of Medicine Chicago IL., Xu S; Northwestern University Feinberg School of Medicine Chicago IL., Kibbe MR; University of North Carolina Chapel Hill NC., Leeuwenburgh C; University of Florida Gainesville FL., Manini T; University of Florida Gainesville FL., Forman DE; University of Pittsburgh, Department of Medicine, Geriatric Research Education, and Clinical Center Pittsburgh PA., Treat-Jacobson D; University of Minnesota School of Nursing Minneapolis MN., Polonsky TS; Department of Medicine University of Chicago Chicago IL., Bazzano L; Tulane University New Orleans LA., Ferrucci L; National Institute on Aging Division of Intramural Research Bethesda MD., Guralnik J; Department of Epidemiology University of Maryland Baltimore MD., Lloyd-Jones DM; Northwestern University Feinberg School of Medicine Chicago IL., McDermott MM; Northwestern University Feinberg School of Medicine Chicago IL. |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of the American Heart Association [J Am Heart Assoc] 2022 Aug 02; Vol. 11 (15), pp. e025063. Date of Electronic Publication: 2022 Jul 27. |
| DOI: |
10.1161/JAHA.121.025063 |
| Abstrakt: |
Background In people with peripheral artery disease, post hoc analyses of the LITE (Low Intensity Exercise Intervention in Peripheral Artery Disease) randomized trial were conducted to evaluate the effects of walking exercise at a pace inducing ischemic leg symptoms on walking velocity and the Short Physical Performance Battery, compared with walking exercise without ischemic leg symptoms and compared with a nonexercising control group. Methods and Results Participants with peripheral artery disease were randomized to: home-based walking exercise that induced ischemic leg symptoms; home-based walking exercise conducted without ischemic leg symptoms; or a nonexercising control group for 12 months. Outcomes were change of walking velocity over 4 m and change of the Short Physical Performance Battery (0-12, with 12=best) at 6- and 12-month follow-up. A total of 264 participants (48% women, 61% Black race) were included. Compared with walking exercise without ischemic symptoms, walking exercise that induced ischemic symptoms improved change in usual-paced walking velocity over 4 m at 6-month (0.056 m/s [95% CI, 0.019-0.094 m/s]; P <0.01) and 12-month follow-up (0.084 m/s [95% CI, 0.049-0.120 m/s]; P <0.01), change in fast-paced of walking velocity over 4 m at 6-month follow-up ( P =0.03), and change in the Short Physical Performance Battery at 12-month follow-up (0.821 [95% CI, 0.309-1.334]; P <0.01). Compared with control, walking exercise at a pace inducing ischemic symptoms improved change in usual-paced walking velocity over 4 m at 6-month follow-up (0.066 m/s [95% CI, 0.021-0.111 m/s]; P <0.01). Conclusions In people with peripheral artery disease, those who walked for exercise at a comfortable pace without ischemic leg symptoms slowed their walking speed during daily life and worsened the Short Physical Performance Battery score, a potentially harmful effect, compared with people who walked for exercise at a pace inducing ischemic leg symptoms. Compared with a control group who did not exercise, home-based walking exercise at a pace inducing ischemic leg symptoms significantly improved change of walking velocity over 4 m at 6-month follow-up, but this benefit did not persist at 12-month follow-up. Registration URL: https://www.clinicaltrials.gov; Unique identifier: NCT02538900. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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