| Autor: |
Bouazza A; Biology and Organisms Physiology Laboratory, Bioenergetics and Intermediary Metabolism Team, Nutrition and Dietetics in Human Pathologies Post Graduate School, University of Sciences and Technology Houari Boumediene, El Alia, Bab Ezzouar, Algiers 16123, Algeria., Favier R; Laboratory of Fundamental and Applied Bioenergetics (LBFA), INSERM U1055, Univ. Grenoble Alpes, 16042 Grenoble, France., Fontaine E; Laboratory of Fundamental and Applied Bioenergetics (LBFA), INSERM U1055, Univ. Grenoble Alpes, 16042 Grenoble, France., Leverve X; Laboratory of Fundamental and Applied Bioenergetics (LBFA), INSERM U1055, Univ. Grenoble Alpes, 16042 Grenoble, France., Koceir EA; Biology and Organisms Physiology Laboratory, Bioenergetics and Intermediary Metabolism Team, Nutrition and Dietetics in Human Pathologies Post Graduate School, University of Sciences and Technology Houari Boumediene, El Alia, Bab Ezzouar, Algiers 16123, Algeria. |
| Abstrakt: |
3,5-Diiodothyronine (3,5-T2) has been shown to exert pleiotropic beneficial effects. In this study we investigated whether 3,5-T2 prevent several energy metabolism disorders related to type 2 diabetes mellitus (T2DM) in gerbils diabetes-prone P. obesus . 157 male gerbils were randomly to Natural Diet (ND-controlled) or a HED (High-Energy Diet) divided in: HED- controlled, HED-3,5-T2 and HED- Placebo groups. 3,5-T2 has been tested at 25 µg dose and was administered under subcutaneous pellet implant during 10 weeks. Isolated hepatocytes were shortly incubated with 3,5-T2 at 10 -6 M and 10 -9 M dose in the presence energetic substrates. 3,5-T2 treatment reduce visceral adipose tissue, prevent the insulin resistance, attenuated hyperglycemia, dyslipidemia, and reversed liver steatosis in diabetes P. obesus . 3,5-T2 decreased gluconeogenesis, increased ketogenesis and enhanced respiration capacity. 3,5-T2 potentiates redox and phosphate potential both in cytosol and mitochondrial compartment. The use of 3,5-T2 as a natural therapeutic means to regulate cellular energy metabolism. We suggest that 3,5-T2 may help improve the deleterious course of obesity and T2DM, but cannot replace medical treatment. |
