| Autor: |
Tikhonova EG; Institute of Biomedical Chemistry, 10 Pogodinskaya St.,119121 Moscow, Russia., Tereshkina YA; Institute of Biomedical Chemistry, 10 Pogodinskaya St.,119121 Moscow, Russia., Kostryukova LV; Institute of Biomedical Chemistry, 10 Pogodinskaya St.,119121 Moscow, Russia., Khudoklinova YY; Institute of Biomedical Chemistry, 10 Pogodinskaya St.,119121 Moscow, Russia., Sanzhakov MA; Institute of Biomedical Chemistry, 10 Pogodinskaya St.,119121 Moscow, Russia., Tamarovskaya AO; Joint Institute for Nuclear Research, 6 Joliot-Curie St, 141980 Dubna, Russia., Ivankov OI; Joint Institute for Nuclear Research, 6 Joliot-Curie St, 141980 Dubna, Russia., Kiselev MA; Joint Institute for Nuclear Research, 6 Joliot-Curie St, 141980 Dubna, Russia. |
| Abstrakt: |
Nonsteroidal anti-inflammatory drugs (NSAIDs), inhibitors of cyclooxygenase-2, an enzyme involved in the formation of anti-inflammatory prostaglandin PGE2, are the most common treatment for chronic inflammatory diseases, such as, for example, arthritis. One of the most commonly used drugs of this class is indomethacin, a derivative of indolylacetic acid. In this work, we studied the physicochemical properties of the phospholipid composition of indomethacin obtained earlier (codenamed "Indolip") and the effect of freeze drying on its parameters. It was shown that the properties such as particle size, light transmission, phospholipid oxidation index did not change significantly, which indicated the stability of the drug after lyophilization. Measurement of the spectra of small-angle neutron scattering has shown that morphologically, Indolip is a vesicle whose radius is five times greater than the value of the bilayer thickness. |
