A Genome-Wide Search for Candidate Genes of Meat Production in Jalgin Merino Considering Known Productivity Genes.

Autor:	Krivoruchko A; FSBSI North Caucasian Federal Scientific Agrarian Center, 356241 Mikhailovsk, Russia.; Federal State Autonomous Educational Institution of Higher Education North Caucasian Federal University, 355017 Stavropol, Russia., Surov A; FSBSI North Caucasian Federal Scientific Agrarian Center, 356241 Mikhailovsk, Russia., Skokova A; FSBSI North Caucasian Federal Scientific Agrarian Center, 356241 Mikhailovsk, Russia., Kanibolotskaya A; FSBSI North Caucasian Federal Scientific Agrarian Center, 356241 Mikhailovsk, Russia., Saprikina T; FSBSI North Caucasian Federal Scientific Agrarian Center, 356241 Mikhailovsk, Russia., Kukharuk M; Federal State Autonomous Educational Institution of Higher Education North Caucasian Federal University, 355017 Stavropol, Russia., Yatsyk O; FSBSI North Caucasian Federal Scientific Agrarian Center, 356241 Mikhailovsk, Russia.
Jazyk:	angličtina
Zdroj:	Genes [Genes (Basel)] 2022 Jul 26; Vol. 13 (8). Date of Electronic Publication: 2022 Jul 26.
DOI:	10.3390/genes13081337
Abstrakt:	In a group of Jalgin merino rams with no significant influence on the dispersion of the phenotypes of known productivity genes ( MSTN , MEF2B , FABP4 , etc.), a genome-wide search for associations of individual polymorphisms with intravital indicators of meat productivity was performed. Using the Ovine Infinium HD BeadChip 600K, 606,000 genome loci were evaluated. Twenty-three substitutions were found to be significantly associated with external measurements of the body and ultrasonic parameters. This made it possible to describe 14 candidate genes, the structural features of which can cause changes in animal phenotypes. No closely spaced genes were found for two substitutions. The identified polymorphisms were found in the exons, introns, and adjacent regions of the following genes and transcripts: CDCA2 , ENSOARG00000014477 , C4BPA , RIPOR2 , ENSOARG00000007198 , ENSOARG00000026965 (LincRNA) , ENSOARG00000026436 (LincRNA) , ENSOARG00000026782 (LincRNA) , TENM3 , RTL8A , MOSPD1 , RTL8С , RIMS2 , and P4HA3 . The detected genes affect the metabolic pathways of cell differentiation and proliferation and are associated with the regulation of the immune system. This confirms their possible participation in the formation of the phenotypes of productivity parameters in animals and indicates the need for further study of the structure of candidate genes in order to identify their internal polymorphisms. Competing Interests: The authors declare that they have no conflicts of interest.
Databáze:	MEDLINE
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