The Long and Winding Road: An Overview of the Immunological Landscape of Intracranial Meningiomas.

Autor: Giammalva GR; Neurosurgical Clinic, AOUP 'Paolo Giaccone', Post Graduate Residency Program in Neurologic Surgery, Department of Biomedicine Neurosciences and Advanced Diagnostics, School of Medicine, University of Palermo, 90127 Palermo, Italy., Brunasso L; Neurosurgical Clinic, AOUP 'Paolo Giaccone', Post Graduate Residency Program in Neurologic Surgery, Department of Biomedicine Neurosciences and Advanced Diagnostics, School of Medicine, University of Palermo, 90127 Palermo, Italy., Paolini F; Neurosurgical Clinic, AOUP 'Paolo Giaccone', Post Graduate Residency Program in Neurologic Surgery, Department of Biomedicine Neurosciences and Advanced Diagnostics, School of Medicine, University of Palermo, 90127 Palermo, Italy., Costanzo R; Neurosurgical Clinic, AOUP 'Paolo Giaccone', Post Graduate Residency Program in Neurologic Surgery, Department of Biomedicine Neurosciences and Advanced Diagnostics, School of Medicine, University of Palermo, 90127 Palermo, Italy., Bonosi L; Neurosurgical Clinic, AOUP 'Paolo Giaccone', Post Graduate Residency Program in Neurologic Surgery, Department of Biomedicine Neurosciences and Advanced Diagnostics, School of Medicine, University of Palermo, 90127 Palermo, Italy., Benigno UE; Neurosurgical Clinic, AOUP 'Paolo Giaccone', Post Graduate Residency Program in Neurologic Surgery, Department of Biomedicine Neurosciences and Advanced Diagnostics, School of Medicine, University of Palermo, 90127 Palermo, Italy., Ferini G; Department of Radiation Oncology, REM Radioterapia srl, 95125 Catania, Italy., Sava S; Department of Medical Oncology, Istituto Oncologico del Mediterraneo, 95029 Viagrande, Italy., Colarossi C; Pathology Unit, Department of Experimental Oncology, Mediterranean Institute of Oncology, 95029 Viagrande, Italy., Umana GE; Department of Neurosurgery, Cannizzaro Hospital, Trauma Center, Gamma Knife Center, 95125 Catania, Italy., Gerardi RM; Neurosurgical Clinic, AOUP 'Paolo Giaccone', Post Graduate Residency Program in Neurologic Surgery, Department of Biomedicine Neurosciences and Advanced Diagnostics, School of Medicine, University of Palermo, 90127 Palermo, Italy., Sturiale CL; Department of Neurosurgery, Fondazione Policlinico Universitario 'A. Gemelli' IRCCS, Università Cattolica del Sacro Cuore, 00168 Rome, Italy., Albanese A; Department of Neurosurgery, Fondazione Policlinico Universitario 'A. Gemelli' IRCCS, Università Cattolica del Sacro Cuore, 00168 Rome, Italy., Iacopino DG; Neurosurgical Clinic, AOUP 'Paolo Giaccone', Post Graduate Residency Program in Neurologic Surgery, Department of Biomedicine Neurosciences and Advanced Diagnostics, School of Medicine, University of Palermo, 90127 Palermo, Italy., Maugeri R; Neurosurgical Clinic, AOUP 'Paolo Giaccone', Post Graduate Residency Program in Neurologic Surgery, Department of Biomedicine Neurosciences and Advanced Diagnostics, School of Medicine, University of Palermo, 90127 Palermo, Italy.
Jazyk: angličtina
Zdroj: Cancers [Cancers (Basel)] 2022 Jul 26; Vol. 14 (15). Date of Electronic Publication: 2022 Jul 26.
DOI: 10.3390/cancers14153639
Abstrakt: The role of immunotherapy is gaining ever-increasing interest in the neuro-oncological field, and this is also expanding to the management of intracranial meningioma. Meningiomas are still the most common primary adult tumor of the CNS, and even though surgery and/or radiotherapy still represent cornerstones of their treatment, recent findings strongly support the potential role of specific immune infiltrate cells, their features and genomics, for the application of personalized treatments and prognostic implications. According to the PRISMA guidelines, systematic research in the most updated platform was performed in order to provide a descriptive and complete overview about the characteristics, role and potential implications of immunology in meningioma tumors. Seventy articles were included and analyzed in the present paper. The meningioma microenvironment reveals complex immune tumor-immune cells interactions that may definitely influence tumor progression, as well as offering unexpected opportunities for treatment.
Databáze: MEDLINE
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