Kathryn V. Holmes: A Career of Contributions to the Coronavirus Field.

Autor: Bonavia A; Vaccine Development, Bill & Melinda Gates Medical Research Institute, Cambridge, MA 02139, USA., Dominguez SR; Department of Pediatrics-Infectious Diseases, University of Colorado School of Medicine, Aurora, CO 80045, USA., Dveksler G; Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA., Gagneten S; Division of Viral Products, Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20993, USA., Howard M; Battelle Memorial Institute, Columbus, OH 43201, USA., Jeffers S; GenSight Biologics, 75012 Paris, France., Qian Z; Institute of Pathogen Biology, Chinese Academy of Medical Sciences, Beijing 100050, China., Smith MK; General Dynamics Information Technology, Falls Church, VA 22030, USA., Thackray LB; Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA., Tresnan DB; Safety Surveillance and Risk Management, Worldwide Safety, Pfizer, Groton, CT 06340, USA., Wentworth DE; COVID-19 Emergency Response, Virology Surveillance and Diagnosis Branch, Influenza Division, Centers for Disease Control and Prevention, Atlanta, GA 30329-4027, USA., Wessner DR; Departments of Biology and Public Health, Davidson College, Davidson, NC 28035, USA., Williams RK; NIAID, NIH, Bethesda, MD 20817, USA., Miura TA; Department of Biological Sciences, University of Idaho, Moscow, ID 83844, USA.
Jazyk: angličtina
Zdroj: Viruses [Viruses] 2022 Jul 20; Vol. 14 (7). Date of Electronic Publication: 2022 Jul 20.
DOI: 10.3390/v14071573
Abstrakt: Over the past two years, scientific research has moved at an unprecedented rate in response to the COVID-19 pandemic. The rapid development of effective vaccines and therapeutics would not have been possible without extensive background knowledge on coronaviruses developed over decades by researchers, including Kathryn (Kay) Holmes. Kay's research team discovered the first coronavirus receptors for mouse hepatitis virus and human coronavirus 229E and contributed a wealth of information on coronaviral spike glycoproteins and receptor interactions that are critical determinants of host and tissue specificity. She collaborated with several research laboratories to contribute knowledge in additional areas, including coronaviral pathogenesis, epidemiology, and evolution. Throughout her career, Kay was an extremely dedicated and thoughtful mentor to numerous graduate students and post-doctoral fellows. This article provides a review of her contributions to the coronavirus field and her exemplary mentoring.
Databáze: MEDLINE
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