A Retrospective Study of the Seroprevalence of Dengue Virus and Chikungunya Virus Exposures in Nigeria, 2010-2018.

Autor: Ekong PS; Central Diagnostic Laboratory, National Veterinary Research Institute, Vom P.M.B 01, Nigeria.; Veterinary Medicine Teaching and Research Center, School of Veterinary Medicine, University of California Davis, Tulare, CA 93274, USA., Aworh MK; Department of Veterinary and Pests Control Services, Federal Ministry of Agriculture & Rural Development, Abuja 900247, Nigeria., Grossi-Soyster EN; Department of Pediatrics, Division of Infectious Disease, Stanford University School of Medicine, Stanford, CA 94305, USA., Wungak YS; Central Diagnostic Laboratory, National Veterinary Research Institute, Vom P.M.B 01, Nigeria., Maurice NA; Central Diagnostic Laboratory, National Veterinary Research Institute, Vom P.M.B 01, Nigeria., Altamirano J; Department of Pediatrics, Division of Infectious Disease, Stanford University School of Medicine, Stanford, CA 94305, USA., Ekong MJ; Medical Microbiology and Parasitology Department, University College Hospital, Ibadan P.M.B 3017, Nigeria., Olugasa BO; Centre for Control and Prevention of Zoonoses, Department of Veterinary Public Health and Preventive Medicine, University of Ibadan, Ibadan P.M.B 3017, Nigeria., Nwosuh CI; Central Diagnostic Laboratory, National Veterinary Research Institute, Vom P.M.B 01, Nigeria., Shamaki D; Central Diagnostic Laboratory, National Veterinary Research Institute, Vom P.M.B 01, Nigeria., Faburay B; Scientific Liaison Services Section, Foreign Animal Disease Diagnostic Laboratory, National Veterinary Services Laboratories, Animal and Plant Health Inspection Service (APHIS), Plum Island Animal Disease Center, United States Department of Agriculture, New York, NY 11957, USA., LaBeaud DA; Department of Pediatrics, Division of Infectious Disease, Stanford University School of Medicine, Stanford, CA 94305, USA.
Jazyk: angličtina
Zdroj: Pathogens (Basel, Switzerland) [Pathogens] 2022 Jul 04; Vol. 11 (7). Date of Electronic Publication: 2022 Jul 04.
DOI: 10.3390/pathogens11070762
Abstrakt: Arboviruses are important public health threats in many regions of the world. Nigeria has experienced outbreaks of arboviruses over the past decades, leading to concerns of widespread endemicity, which are frequently misdiagnosed. This study aimed to determine the seroprevalence of dengue virus (DENV) (a flavivirus) and chikungunya virus (CHIKV) (an alphavirus) infections in three major population centers of Nigeria. A convenience sample of 701 sera was collected from both healthy and febrile participants between August 2010 and March 2018. Sera were tested for prior exposure to CHIKV virus and DENV using indirect IgG ELISA. Results showed that 54.1% (379/701) of participants were seropositive for anti-DENV antibodies, 41.3% (290/701) were seropositive for anti-CHIKV antibodies, and 20.1% (141/701) had previous exposure to both. The seropositivity for prior CHIKV exposure and prior exposure to DENV and CHIKV was significantly associated with age (CHIKV: OR = 2.7 (95% CI: 1.7-4.3); DENV and CHIKV: OR = 2.2 (95% CI: 1.2-4.0) for adults compared to participants under 18 years old). Overall, the high seropositivity across all age groups suggests that arboviral infections are prevalent in Nigeria and indicates that surveillance and further epidemiological studies are required to determine the true burden of these infections and the spectrum of diseases associated with these exposures.
Databáze: MEDLINE