| Autor: |
Leskovská J; Department of Chemical Theory of Drugs, Faculty of Pharmacy, Comenius University in Bratislava, Kalinčiakova 8, 83104 Bratislava, Slovakia., Miklášová N; Department of Chemical Theory of Drugs, Faculty of Pharmacy, Comenius University in Bratislava, Kalinčiakova 8, 83104 Bratislava, Slovakia., Kubelac PM; Institute of Oncology 'Prof.Dr.I.Chiricuta', RO-400015 Cluj-Napoca, Romania.; Department of Oncology, 'Iuliu Hatieganu' University of Medicine and Pharmacy, RO-400012 Cluj-Napoca, Romania., Achimaş-Cadariu P; Institute of Oncology 'Prof.Dr.I.Chiricuta', RO-400015 Cluj-Napoca, Romania.; Department of Oncological Surgery and Gynecological Oncology, 'Iuliu Hatieganu' University of Medicine and Pharmacy, RO-400012 Cluj-Napoca, Romania., Valentová J; Department of Chemical Theory of Drugs, Faculty of Pharmacy, Comenius University in Bratislava, Kalinčiakova 8, 83104 Bratislava, Slovakia., Markuliak M; Department of Chemical Theory of Drugs, Faculty of Pharmacy, Comenius University in Bratislava, Kalinčiakova 8, 83104 Bratislava, Slovakia., Fischer-Fodor E; Institute of Oncology 'Prof.Dr.I.Chiricuta', RO-400015 Cluj-Napoca, Romania. |
| Abstrakt: |
So far, the polyphenolic components of turmeric have shown a significant pharmacological preventative activity for a wide spectrum of diseases, including oncological disorders. This type of natural product could be of great interest for the inhibition of cancer cell proliferation, displaying less side effects in comparison to classical chemotherapeutics. The poor bioavailability and quick metabolism of such natural compounds require new investigative methods to improve their stability in the organisms. A synthetic approach to increase the efficiency of curcuminoids is to coordinate them to metals through the beta-dicarbonyl moiety. We report the synthesis and the biological attempts on human ovarian carcinoma A2780 of ruthenium(II) complexes 1 - 4 , containing curcuminoid ligands. The cytotoxicity of complexes 1 - 4 proves their antiproliferative capability, and a correlation between the IC 50 values and NF- κ B transcription factor, FGF-2, and MMP-9 levels was figured out through the principal component analysis (PCA). |
