Pre- and Postnatal Dietary Exposure to a Pesticide Cocktail Disrupts Ovarian Functions in 8-Week-Old Female Mice.

Autor: Dopavogui L; Toxalim (Research Centre in Food Toxicology), INRA, ENVT, INP-Purpan, Université Paul Sabatier, 31062 Toulouse, France., Cadoret F; Service de Médecine de la Reproduction, Hôpital Paule de Viguier, CHU Toulouse, 330 Avenue de Grande Bretagne, 31059 Toulouse, France.; Développement Embryonnaire, Fertilité et Environnement (DEFE), UMR1203 INSERM-Universités Toulouse et Montpellier, Toulouse Teaching Hospital Group, 330 Avenue de Grande Bretagne, 31059 Toulouse, France., Loison G; Service de Médecine de la Reproduction, Hôpital Paule de Viguier, CHU Toulouse, 330 Avenue de Grande Bretagne, 31059 Toulouse, France.; Développement Embryonnaire, Fertilité et Environnement (DEFE), UMR1203 INSERM-Universités Toulouse et Montpellier, Toulouse Teaching Hospital Group, 330 Avenue de Grande Bretagne, 31059 Toulouse, France., El Fouikar S; Toxalim, EXPER Group, Toulouse National Vetenary School, 23 Chemin des Capelles, CEDEX 3, 31076 Toulouse, France., Frenois FX; Imag'IN Platform of the IUCT, Department of Pathology, Cancer Institute University of Toulouse-Oncopole, 1 Avenue Irène Joliot-Curie, CEDEX 9, 31059 Toulouse, France., Giton F; AP-HP, Pôle Biologie-Pathologie Henri Mondor, INSERM IMRB U955, Faculté de Santé, 8 Rue du Général Sarrail, CEDEX, 94010 Créteil, France., Ellero-Simatos S; Toxalim (Research Centre in Food Toxicology), INRA, ENVT, INP-Purpan, Université Paul Sabatier, 31062 Toulouse, France., Lasserre F; Toxalim (Research Centre in Food Toxicology), INRA, ENVT, INP-Purpan, Université Paul Sabatier, 31062 Toulouse, France., Polizzi A; Toxalim (Research Centre in Food Toxicology), INRA, ENVT, INP-Purpan, Université Paul Sabatier, 31062 Toulouse, France., Rives C; Toxalim (Research Centre in Food Toxicology), INRA, ENVT, INP-Purpan, Université Paul Sabatier, 31062 Toulouse, France., Loiseau N; Toxalim (Research Centre in Food Toxicology), INRA, ENVT, INP-Purpan, Université Paul Sabatier, 31062 Toulouse, France., Léandri RD; Service de Médecine de la Reproduction, Hôpital Paule de Viguier, CHU Toulouse, 330 Avenue de Grande Bretagne, 31059 Toulouse, France.; Toxalim, EXPER Group, Toulouse National Vetenary School, 23 Chemin des Capelles, CEDEX 3, 31076 Toulouse, France., Gatimel N; Service de Médecine de la Reproduction, Hôpital Paule de Viguier, CHU Toulouse, 330 Avenue de Grande Bretagne, 31059 Toulouse, France.; Développement Embryonnaire, Fertilité et Environnement (DEFE), UMR1203 INSERM-Universités Toulouse et Montpellier, Toulouse Teaching Hospital Group, 330 Avenue de Grande Bretagne, 31059 Toulouse, France., Gamet-Payrastre L; Toxalim (Research Centre in Food Toxicology), INRA, ENVT, INP-Purpan, Université Paul Sabatier, 31062 Toulouse, France.
Jazyk: angličtina
Zdroj: International journal of molecular sciences [Int J Mol Sci] 2022 Jul 07; Vol. 23 (14). Date of Electronic Publication: 2022 Jul 07.
DOI: 10.3390/ijms23147525
Abstrakt: Female infertility has a multifactorial origin, and exposure to contaminants, including pesticides, with endocrine-disrupting properties is considered to be involved in this reproductive disorder, especially when it occurs during early life. Pesticides are present in various facets of the environment, and consumers are exposed to a combination of multiple pesticide residues through food intake. The consequences of such exposure with respect to female fertility are not well known. Therefore, we aimed to assess the impact of pre- and postnatal dietary exposure to a pesticide mixture on folliculogenesis, a crucial process in female reproduction. Mice were exposed to the acceptable daily intake levels of six pesticides in a mixture (boscalid, captan, chlorpyrifos, thiacloprid, thiophanate and ziram) from foetal development until 8 weeks old. Female offspring presented with decreased body weight at weaning, which was maintained at 8 weeks old. This was accompanied by an abnormal ovarian ultrastructure, a drastic decrease in the number of corpora lutea and progesterone levels and an increase in ovary cell proliferation. In conclusion, this study shows that this pesticide mixture that can be commonly found in fruits in Europe, causing endocrine disruption in female mice with pre- and postnatal exposure by disturbing folliculogenesis, mainly in the luteinisation process.
Databáze: MEDLINE
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