Mechanical Properties of the Extracellular Environment of Human Brain Cells Drive the Effectiveness of Drugs in Fighting Central Nervous System Cancers.

Autor: Cieśluk M; Department of Medical Microbiology and Nanobiomedical Engineering, Medical University of Białystok, PL-15222 Białystok, Poland., Pogoda K; Institute of Nuclear Physics Polish Academy of Sciences, PL-31342 Kraków, Poland., Piktel E; Independent Laboratory of Nanomedicine, Medical University of Białystok, PL-15222 Białystok, Poland., Wnorowska U; Department of Medical Microbiology and Nanobiomedical Engineering, Medical University of Białystok, PL-15222 Białystok, Poland., Deptuła P; Department of Medical Microbiology and Nanobiomedical Engineering, Medical University of Białystok, PL-15222 Białystok, Poland., Bucki R; Department of Medical Microbiology and Nanobiomedical Engineering, Medical University of Białystok, PL-15222 Białystok, Poland.
Jazyk: angličtina
Zdroj: Brain sciences [Brain Sci] 2022 Jul 15; Vol. 12 (7). Date of Electronic Publication: 2022 Jul 15.
DOI: 10.3390/brainsci12070927
Abstrakt: The evaluation of nanomechanical properties of tissues in health and disease is of increasing interest to scientists. It has been confirmed that these properties, determined in part by the composition of the extracellular matrix, significantly affect tissue physiology and the biological behavior of cells, mainly in terms of their adhesion, mobility, or ability to mutate. Importantly, pathophysiological changes that determine disease development within the tissue usually result in significant changes in tissue mechanics that might potentially affect the drug efficacy, which is important from the perspective of development of new therapeutics, since most of the currently used in vitro experimental models for drug testing do not account for these properties. Here, we provide a summary of the current understanding of how the mechanical properties of brain tissue change in pathological conditions, and how the activity of the therapeutic agents is linked to this mechanical state.
Competing Interests: The authors declare no conflict of interest.
Databáze: MEDLINE
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