Autophagy: A Key Player in Pancreatic Cancer Progression and a Potential Drug Target.

Autor: Gillson J; Faculty of Medicine and Health, University of Sydney, Camperdown, Sydney, NSW 2050, Australia.; Bill Walsh Translational Cancer Research Laboratory, Kolling Institute of Medical Research, St Leonards, Sydney, NSW 2065, Australia., Abd El-Aziz YS; Faculty of Medicine and Health, University of Sydney, Camperdown, Sydney, NSW 2050, Australia.; Bill Walsh Translational Cancer Research Laboratory, Kolling Institute of Medical Research, St Leonards, Sydney, NSW 2065, Australia.; Oral Pathology Department, Faculty of Dentistry, Tanta University, Tanta 31527, Egypt., Leck LYW; Faculty of Medicine and Health, University of Sydney, Camperdown, Sydney, NSW 2050, Australia.; Bill Walsh Translational Cancer Research Laboratory, Kolling Institute of Medical Research, St Leonards, Sydney, NSW 2065, Australia.; Cancer Drug Resistance and Stem Cell Program, University of Sydney, Sydney, NSW 2006, Australia., Jansson PJ; Faculty of Medicine and Health, University of Sydney, Camperdown, Sydney, NSW 2050, Australia.; Bill Walsh Translational Cancer Research Laboratory, Kolling Institute of Medical Research, St Leonards, Sydney, NSW 2065, Australia.; Cancer Drug Resistance and Stem Cell Program, University of Sydney, Sydney, NSW 2006, Australia., Pavlakis N; Faculty of Medicine and Health, University of Sydney, Camperdown, Sydney, NSW 2050, Australia.; Bill Walsh Translational Cancer Research Laboratory, Kolling Institute of Medical Research, St Leonards, Sydney, NSW 2065, Australia., Samra JS; Faculty of Medicine and Health, University of Sydney, Camperdown, Sydney, NSW 2050, Australia.; Upper GI Surgical Unit, Royal North Shore Hospital and North Shore Private Hospital, St Leonards, Sydney, NSW 2065, Australia.; Australian Pancreatic Centre, St Leonards, Sydney, NSW 2065, Australia., Mittal A; Faculty of Medicine and Health, University of Sydney, Camperdown, Sydney, NSW 2050, Australia.; Upper GI Surgical Unit, Royal North Shore Hospital and North Shore Private Hospital, St Leonards, Sydney, NSW 2065, Australia.; Australian Pancreatic Centre, St Leonards, Sydney, NSW 2065, Australia.; School of Medicine, University of Notre Dame, Darlinghurst, Sydney, NSW 2010, Australia., Sahni S; Faculty of Medicine and Health, University of Sydney, Camperdown, Sydney, NSW 2050, Australia.; Bill Walsh Translational Cancer Research Laboratory, Kolling Institute of Medical Research, St Leonards, Sydney, NSW 2065, Australia.; Australian Pancreatic Centre, St Leonards, Sydney, NSW 2065, Australia.
Jazyk: angličtina
Zdroj: Cancers [Cancers (Basel)] 2022 Jul 20; Vol. 14 (14). Date of Electronic Publication: 2022 Jul 20.
DOI: 10.3390/cancers14143528
Abstrakt: Pancreatic cancer is known to have the lowest survival outcomes among all major cancers, and unfortunately, this has only been marginally improved over last four decades. The innate characteristics of pancreatic cancer include an aggressive and fast-growing nature from powerful driver mutations, a highly defensive tumor microenvironment and the upregulation of advantageous survival pathways such as autophagy. Autophagy involves targeted degradation of proteins and organelles to provide a secondary source of cellular supplies to maintain cell growth. Elevated autophagic activity in pancreatic cancer is recognized as a major survival pathway as it provides a plethora of support for tumors by supplying vital resources, maintaining tumour survival under the stressful microenvironment and promoting other pathways involved in tumour progression and metastasis. The combination of these features is unique to pancreatic cancer and present significant resistance to chemotherapeutic strategies, thus, indicating a need for further investigation into therapies targeting this crucial pathway. This review will outline the autophagy pathway and its regulation, in addition to the genetic landscape and tumor microenvironment that contribute to pancreatic cancer severity. Moreover, this review will also discuss the mechanisms of novel therapeutic strategies that inhibit autophagy and how they could be used to suppress tumor progression.
Databáze: MEDLINE
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