Bacterial Colonization Incidence before and after Indwelling Double-J Ureteral Stents.

Autor:	Kaliyeva S; Department of Clinical Pharmacology and Evidence-Based Medicine, NCJSC Karaganda Medical University, Karaganda 100000, Kazakhstan., Simokhina N; Department of Clinical Pharmacology and Evidence-Based Medicine, NCJSC Karaganda Medical University, Karaganda 100000, Kazakhstan., Lavrinenko A; Scientific Research Laboratory, NCJSC Karaganda Medical University, Karaganda 100000, Kazakhstan., Zhussupova G; National Center for Rational Use of Medicines, Nur-Sultan 010000, Kazakhstan., Zhunusov S; Department of Surgery Diseases, NCJSC Karaganda Medical University, Karaganda 100000, Kazakhstan., Semenikhina P; Neurology, Psychiatry and Rehabilitation Department, NCJSC Karaganda Medical University, Karaganda 100000, Kazakhstan., Bikbatyrova Y; Department of Clinical Pharmacology and Evidence-Based Medicine, NCJSC Karaganda Medical University, Karaganda 100000, Kazakhstan., Yelmagambetov B; 'SANAT' National Education Development Science Center, Nur-Sultan 010000, Kazakhstan., Myasnikova Z; Department of Clinical Pharmacology and Evidence-Based Medicine, NCJSC Karaganda Medical University, Karaganda 100000, Kazakhstan.
Jazyk:	angličtina
Zdroj:	Antibiotics (Basel, Switzerland) [Antibiotics (Basel)] 2022 Jun 24; Vol. 11 (7). Date of Electronic Publication: 2022 Jun 24.
DOI:	10.3390/antibiotics11070850
Abstrakt:	The upper urinary tract stenting allows to restore the ureteral patency in various situations. However, one of the main disadvantages of stenting is bacterial contamination, which can be a source of persistent infections that hardly respond to antibiotic therapy. The aim of this study was to investigate the local spectrum of bacterial pathogens and their susceptibility to antibiotics in order to optimize antibacterial therapy after upper urinary tract stenting. A prospective observational study was conducted in which 140 urine samples were examined (70 before stenting and 70 after stenting). Bacterial growth was detected in 37 patients (52.8%) before stenting and in 43 patients (61.4%) after stenting. E. coli (13 (28.8%)) and Streptococcus spp. (8 (17.6%)) strains were more commonly detected before stenting; P. aeruginosa (15 (31.2%)) and E. coli (8 (16.6%)) were usually revealed after stenting. The proportion of P. aeruginosa strain s after stenting grew from 4.4% up to 31.2%. E. coli strains were resistant to ampicillin (92.3% before and 100% after stenting). Three strains of E. coli (23.1%) and six strains of P. aeruginosa (40%) were multidrug-resistant. Determination of the bacterial sensitivity to antibiotics and identification of antibiotic-resistant forms of bacteria is a factor in reducing the risk of complications and optimizing antibiotic therapy during the upper urinary tract stenting.
Databáze:	MEDLINE
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