Maternal Fibroblast Growth Factor 21 Levels Decrease during Early Pregnancy in Normotensive Pregnant Women but Are Higher in Preeclamptic Women-A Longitudinal Study.

Autor: Buell-Acosta JD; Department of Physiology, School of Medicine, Universidad Nacional de Colombia, Bogota 11001, Colombia., Garces MF; Department of Physiology, School of Medicine, Universidad Nacional de Colombia, Bogota 11001, Colombia., Parada-Baños AJ; Department of Obstetrics and Gynecology, School of Medicine, Universidad Nacional de Colombia, Bogota 11001, Colombia., Angel-Muller E; Department of Obstetrics and Gynecology, School of Medicine, Universidad Nacional de Colombia, Bogota 11001, Colombia., Paez MC; Department of Public Health, School of Medicine, Universidad Nacional de Colombia, Bogota 11001, Colombia., Eslava-Schmalbach J; Department of Surgery, School of Medicine, Universidad Nacional de Colombia, Bogota 11001, Colombia., Escobar-Cordoba F; Department of Psychiatry, School of Medicine, Universidad Nacional de Colombia, Bogota 11001, Colombia.; Fundación Sueño Vigilia Colombiana, Bogota 111211, Colombia., Caminos-Cepeda SA; School of Medicine, Universidad Pompeu Fabra, 08002 Barcelona, Spain., Lacunza E; Centro de Investigaciones Inmunológicas Básicas y Aplicadas (CINIBA), Facultad de Ciencias Médicas, Universidad Nacional de La Plata, La Plata 1900, Argentina., Castaño JP; Maimonides Institute of Biomedical Research of Cordoba (IMIBIC), Reina Sofia University Hospital, 14004 Cordoba, Spain.; CIBERObn-Physiopathology of Obesity and Nutrition, Intituto de Salud Carlos III, 28029 Madrid, Spain., Nogueiras R; CIBERObn-Physiopathology of Obesity and Nutrition, Intituto de Salud Carlos III, 28029 Madrid, Spain.; Department of Physiology (CIMUS), School of Medicine, Instituto de Investigaciones Sanitarias (IDIS), Universidad de Santiago de Compostela, 15782 Santiago de Compostela, Spain., Dieguez C; CIBERObn-Physiopathology of Obesity and Nutrition, Intituto de Salud Carlos III, 28029 Madrid, Spain.; Department of Physiology (CIMUS), School of Medicine, Instituto de Investigaciones Sanitarias (IDIS), Universidad de Santiago de Compostela, 15782 Santiago de Compostela, Spain., Ruiz-Parra AI; Department of Obstetrics and Gynecology, School of Medicine, Universidad Nacional de Colombia, Bogota 11001, Colombia., Caminos JE; Department of Physiology, School of Medicine, Universidad Nacional de Colombia, Bogota 11001, Colombia.
Jazyk: angličtina
Zdroj: Cells [Cells] 2022 Jul 21; Vol. 11 (14). Date of Electronic Publication: 2022 Jul 21.
DOI: 10.3390/cells11142251
Abstrakt: (1) Background: Fibroblast growth factor 21 (FGF-21) is an endocrine factor involved in glucose and lipid metabolism that exerts pleiotropic effects. The aim of this study was to investigate the serum FGF-21 profile in healthy and mild preeclamptic pregnant women at each trimester of pregnancy; (2) Methods: Serum FGF-21 levels were determined by ELISA in a nested case-control study within a longitudinal cohort study that included healthy (n = 54) and mild preeclamptic (n = 20) pregnant women, women at three months after delivery (n = 20) and eumenorrheic women during the menstrual cycle (n = 20); (3) Results: FGF-21 levels were significantly lower in the mid-luteal phase compared to the early follicular phase of the menstrual cycle in eumenorrheic women (p < 0.01). Maternal levels of FGF-21 were significantly lower in the first and second trimesters and peaked during the third trimester in healthy pregnant women (p < 0.01). Serum levels of FGF-21 in healthy pregnant were significantly lower in the first and second trimester of pregnancy compared with the follicular phase of the menstrual cycle and postpartum (p < 0.01). Serum FGF-21 levels were significantly higher in preeclamptic compared to healthy pregnant women during pregnancy (p < 0.01); (4) Conclusions: These results suggest that a peak of FGF-21 towards the end of pregnancy in healthy pregnancy and higher levels in preeclamptic women might play a critical role that contributes to protecting against the negatives effects of high concentrations of non-esterified fatty acids (NEFA) and hypertensive disorder. Furthermore, FGF-21 might play an important role in reproductive function in healthy eumenorrheic women during the menstrual cycle.
Databáze: MEDLINE
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