Hyaluronic acid-coated Bi:Cu 2 O: an H 2 S-responsive agent for colon cancer with targeted delivery and enhanced photothermal performance.

Autor: Cheng Y; Shanghai Key Laboratory of Molecular Imaging, Shanghai University of Medicine and Health Sciences Affiliated Zhoupu Hospital, Shanghai University of Medicine and Health Sciences, Shanghai, 201318, China.; Shanghai Municipal Education Committee Key Laboratory of Molecular Imaging Probes and Sensors, Shanghai Normal University, Shanghai, 200234, China., Bo H; Department of Pathology, Naval Medical Center of PLA, No. 338 Huaihai West Road, Shanghai, 200052, China., Qin R; Shanghai Key Laboratory of Molecular Imaging, Shanghai University of Medicine and Health Sciences Affiliated Zhoupu Hospital, Shanghai University of Medicine and Health Sciences, Shanghai, 201318, China., Chen F; Shanghai Key Laboratory of Molecular Imaging, Shanghai University of Medicine and Health Sciences Affiliated Zhoupu Hospital, Shanghai University of Medicine and Health Sciences, Shanghai, 201318, China., Xue F; Shanghai Key Laboratory of Molecular Imaging, Shanghai University of Medicine and Health Sciences Affiliated Zhoupu Hospital, Shanghai University of Medicine and Health Sciences, Shanghai, 201318, China. Xueff@sumhs.edu.cn., An L; Shanghai Municipal Education Committee Key Laboratory of Molecular Imaging Probes and Sensors, Shanghai Normal University, Shanghai, 200234, China., Huang G; Shanghai Key Laboratory of Molecular Imaging, Shanghai University of Medicine and Health Sciences Affiliated Zhoupu Hospital, Shanghai University of Medicine and Health Sciences, Shanghai, 201318, China. huangg@sumhs.edu.cn., Tian Q; Shanghai Key Laboratory of Molecular Imaging, Shanghai University of Medicine and Health Sciences Affiliated Zhoupu Hospital, Shanghai University of Medicine and Health Sciences, Shanghai, 201318, China. tianqw@sumhs.edu.cn.
Jazyk: angličtina
Zdroj: Journal of nanobiotechnology [J Nanobiotechnology] 2022 Jul 26; Vol. 20 (1), pp. 346. Date of Electronic Publication: 2022 Jul 26.
DOI: 10.1186/s12951-022-01555-x
Abstrakt: Background: Endogenous hydrogen sulfide (H 2 S)-responsive theranostic agents have attracted extensive attention due to their specificity for colon cancer. However, the development of such agents with high enrichment in tumors and excellent photothermal performance remains challenging.
Results: We prepared hyaluronic acid (HA)-coated Bi-doped cuprous oxide (Bi:Cu 2 O@HA) via a one-pot method. The HA specifically targets colon cancer tumor cells to improve the enrichment of Bi:Cu 2 O@HA at tumor sites, while the doped Bi both enhances the photothermal performance of the H 2 S-triggered Cu 2 O and serves as an agent for tumor imaging. The results in this work demonstrated that the Bi:Cu 2 O@HA nanoparticles exhibit good biocompatibility, target colon cancer tumor cells, facilitate computed tomography imaging, and enhanced H 2 S-responsive photothermal therapy performance, resulting in an excellent therapeutic effect in colon cancer.
Conclusions: The novel Bi:Cu 2 O@HA nanoparticles exhibit excellent tumor targeting and photothermal therapeutic effects, which provide new strategies and insights for colon cancer therapy.
(© 2022. The Author(s).)
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje