Prolonged breastfeeding protects from obesity by hypothalamic action of hepatic FGF21.

Autor:	Pena-Leon V; Endocrine Physiopathology Group, Instituto de Investigación Sanitaria de Santiago de Compostela, Complejo Hospitalario Universitario de Santiago/SERGAS, Santiago de Compostela, Spain.; CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria de Santiago de Compostela, Santiago de Compostela, Spain., Folgueira C; Endocrine Physiopathology Group, Instituto de Investigación Sanitaria de Santiago de Compostela, Complejo Hospitalario Universitario de Santiago/SERGAS, Santiago de Compostela, Spain.; CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria de Santiago de Compostela, Santiago de Compostela, Spain.; CIBEROBN Physiopathology of Obesity and Nutrition, ISCIII, Santiago de Compostela, Spain., Barja-Fernández S; Endocrine Physiopathology Group, Instituto de Investigación Sanitaria de Santiago de Compostela, Complejo Hospitalario Universitario de Santiago/SERGAS, Santiago de Compostela, Spain., Pérez-Lois R; Endocrine Physiopathology Group, Instituto de Investigación Sanitaria de Santiago de Compostela, Complejo Hospitalario Universitario de Santiago/SERGAS, Santiago de Compostela, Spain.; CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria de Santiago de Compostela, Santiago de Compostela, Spain., Da Silva Lima N; CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria de Santiago de Compostela, Santiago de Compostela, Spain., Martin M; Laboratory of Development and Plasticity of the Neuroendocrine Brain, Inserm, University of Lille, Lille, France., Heras V; CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria de Santiago de Compostela, Santiago de Compostela, Spain., Martinez-Martinez S; CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria de Santiago de Compostela, Santiago de Compostela, Spain., Valero P; CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria de Santiago de Compostela, Santiago de Compostela, Spain., Iglesias C; CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria de Santiago de Compostela, Santiago de Compostela, Spain., Duquenne M; Laboratory of Development and Plasticity of the Neuroendocrine Brain, Inserm, University of Lille, Lille, France., Al-Massadi O; Endocrine Physiopathology Group, Instituto de Investigación Sanitaria de Santiago de Compostela, Complejo Hospitalario Universitario de Santiago/SERGAS, Santiago de Compostela, Spain.; CIBEROBN Physiopathology of Obesity and Nutrition, ISCIII, Santiago de Compostela, Spain., Beiroa D; CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria de Santiago de Compostela, Santiago de Compostela, Spain., Souto Y; CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria de Santiago de Compostela, Santiago de Compostela, Spain., Fidalgo M; CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria de Santiago de Compostela, Santiago de Compostela, Spain., Sowmyalakshmi R; Laboratory of Development and Plasticity of the Neuroendocrine Brain, Inserm, University of Lille, Lille, France., Guallar D; CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria de Santiago de Compostela, Santiago de Compostela, Spain., Cunarro J; CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria de Santiago de Compostela, Santiago de Compostela, Spain., Castelao C; Endocrine Physiopathology Group, Instituto de Investigación Sanitaria de Santiago de Compostela, Complejo Hospitalario Universitario de Santiago/SERGAS, Santiago de Compostela, Spain.; CIBEROBN Physiopathology of Obesity and Nutrition, ISCIII, Santiago de Compostela, Spain., Senra A; CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria de Santiago de Compostela, Santiago de Compostela, Spain., González-Saenz P; Endocrine Physiopathology Group, Instituto de Investigación Sanitaria de Santiago de Compostela, Complejo Hospitalario Universitario de Santiago/SERGAS, Santiago de Compostela, Spain., Vázquez-Cobela R; Pediatrics Department, GI Pediatric Nutrition, Galicia Research Unit for Development, Growth and Human Nutrition, Complejo Hospitalario Universitario de Santiago, Santiago de Compostela, Spain., Leis R; Pediatrics Department, GI Pediatric Nutrition, Galicia Research Unit for Development, Growth and Human Nutrition, Complejo Hospitalario Universitario de Santiago, Santiago de Compostela, Spain., Sabio G; CNIC, Madrid, Spain., Mueller-Fielitz H; Institute for Experimental and Clinical Pharmacology and Toxicology, University of Lübeck, Lübeck, Germany., Schwaninger M; Institute for Experimental and Clinical Pharmacology and Toxicology, University of Lübeck, Lübeck, Germany., López M; CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria de Santiago de Compostela, Santiago de Compostela, Spain.; CIBEROBN Physiopathology of Obesity and Nutrition, ISCIII, Santiago de Compostela, Spain., Tovar S; CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria de Santiago de Compostela, Santiago de Compostela, Spain.; CIBEROBN Physiopathology of Obesity and Nutrition, ISCIII, Santiago de Compostela, Spain., Casanueva FF; CIBEROBN Physiopathology of Obesity and Nutrition, ISCIII, Santiago de Compostela, Spain., Valjent E; IGF, University of Montpellier, CNRS, Inserm, Montpellier, France., Diéguez C; CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria de Santiago de Compostela, Santiago de Compostela, Spain.; CIBEROBN Physiopathology of Obesity and Nutrition, ISCIII, Santiago de Compostela, Spain., Prevot V; Laboratory of Development and Plasticity of the Neuroendocrine Brain, Inserm, University of Lille, Lille, France., Nogueiras R; CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria de Santiago de Compostela, Santiago de Compostela, Spain. ruben.nogueiras@usc.es.; CIBEROBN Physiopathology of Obesity and Nutrition, ISCIII, Santiago de Compostela, Spain. ruben.nogueiras@usc.es.; Galician Agency of Innovation (GAIN), Xunta de Galicia, Santiago de Compostela, Spain. ruben.nogueiras@usc.es., Seoane LM; Endocrine Physiopathology Group, Instituto de Investigación Sanitaria de Santiago de Compostela, Complejo Hospitalario Universitario de Santiago/SERGAS, Santiago de Compostela, Spain. luisamaria.seoane@usc.es.; CIBEROBN Physiopathology of Obesity and Nutrition, ISCIII, Santiago de Compostela, Spain. luisamaria.seoane@usc.es.
Jazyk:	angličtina
Zdroj:	Nature metabolism [Nat Metab] 2022 Jul; Vol. 4 (7), pp. 901-917. Date of Electronic Publication: 2022 Jul 25.
DOI:	10.1038/s42255-022-00602-z
Abstrakt:	Early-life determinants are thought to be a major factor in the rapid increase of obesity. However, while maternal nutrition has been extensively studied, the effects of breastfeeding by the infant on the reprogramming of energy balance in childhood and throughout adulthood remain largely unknown. Here we show that delayed weaning in rat pups protects them against diet-induced obesity in adulthood, through enhanced brown adipose tissue thermogenesis and energy expenditure. In-depth metabolic phenotyping in this rat model as well as in transgenic mice reveals that the effects of prolonged suckling are mediated by increased hepatic fibroblast growth factor 21 (FGF21) production and tanycyte-controlled access to the hypothalamus in adulthood. Specifically, FGF21 activates GABA-containing neurons expressing dopamine receptor 2 in the lateral hypothalamic area and zona incerta. Prolonged breastfeeding thus constitutes a protective mechanism against obesity by affecting long-lasting physiological changes in liver-to-hypothalamus communication and hypothalamic metabolic regulation. (© 2022. The Author(s).)
Databáze:	MEDLINE
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