Effects of Sodium/Glucose Cotransporter 2 (SGLT2) Inhibitors on Cardiac Imaging Parameters: A Systematic Review and Meta-analysis of Randomized Controlled Trials.

Autor:	Wee CF; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Teo YH; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Teo YN; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Syn NL; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., See RM; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Leong S; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Yip ASY; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Ong ZX; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Lee CH; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; Department of Cardiology, National University Heart Centre Singapore, Singapore., Chan MY; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; Department of Cardiology, National University Heart Centre Singapore, Singapore., Poh KK; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; Department of Cardiology, National University Heart Centre Singapore, Singapore., Ong CC; Department of Diagnostic Imaging, National University Hospital, Singapore., Teo LL; Department of Diagnostic Imaging, National University Hospital, Singapore., Singh D; Department of Cardiology, National University Heart Centre Singapore, Singapore., Tan BY; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; Division of Neurology, University Medicine Cluster, National University Health System, Singapore., Yeo LL; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; Division of Neurology, University Medicine Cluster, National University Health System, Singapore., Kong WK; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; Department of Cardiology, National University Heart Centre Singapore, Singapore., Yeo TC; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; Department of Cardiology, National University Heart Centre Singapore, Singapore., Wong RC; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; Department of Cardiology, National University Heart Centre Singapore, Singapore., Chai P; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; Department of Cardiology, National University Heart Centre Singapore, Singapore., Sia CH; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; Department of Cardiology, National University Heart Centre Singapore, Singapore. ching_hui_sia@nuhs.edu.sg.
Jazyk:	angličtina
Zdroj:	Journal of cardiovascular imaging [J Cardiovasc Imaging] 2022 Jul; Vol. 30 (3), pp. 153-168.
DOI:	10.4250/jcvi.2021.0159
Abstrakt:	Recent studies have shown that sodium/glucose cotransporter 2 (SGLT2) inhibitors might exert favourable changes on cardiac parameters as observed on cardiovascular imaging. We conducted a systematic review and meta-analysis to determine the effects of SGLT2 inhibitors on cardiac imaging parameters. Four electronic databases (PubMed, Embase, Cochrane, Scopus) were searched for studies in which the effects of SGLT2 inhibitors on cardiac imaging parameters were examined. Studies in which a population was administered SGLT2 inhibitors and analysed by echocardiography and/or cardiac magnetic resonance (CMR) imaging were included. Random-effects pair-wise meta-analysis models were utilized to summarize the studies. A total of 11 randomized controlled trials was included with a combined cohort of 910 patients. Comparing patients receiving SGLT2 inhibitors with subjects receiving placebo, the mean change in CMR-measured left ventricular mass (LVM) was -3.87 g (95% confidence interval [CI], -7.77 to 0.04), that in left ventricular end-systolic volume (LVESV) was -5.96 mL (95% CI, -10.52 to -1.41) for combined LVESV outcomes, that in left atrial volume index (LAVi) was -1.78 mL/m² (95% CI, -3.01 to -0.55) for combined LAVi outcomes, and that in echocardiography-measured E/e' was -0.73 (95% CI, -1.43 to -0.03). Between-group differences were not observed in LVM and LVESV after indexation. The only between-group difference that persisted was for LAVi. Treatment with SGLT2 inhibitors resulted in reduction in LAVi and E/e' on imaging, indicating they might have an effect on outcomes associated with LV diastolic function. Competing Interests: The authors have no financial conflicts of interest. (Copyright © 2022 Korean Society of Echocardiography.)
Databáze:	MEDLINE
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