Associations between repeated measures of urinary phthalate metabolites and biomarkers of oxidative stress in a rural agricultural cohort of children with asthma.

Autor: Babadi RS; Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98195, USA. Electronic address: rbabadi@uw.edu., Riederer AM; Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98195, USA. Electronic address: anneried@uw.edu., Sampson PD; Department of Statistics, University of Washington, Seattle, WA 98195, USA. Electronic address: pds@uw.edu., Sathyanarayana S; Seattle Children's Research Institute, Seattle, WA 98145, USA; Department of Pediatrics, University of Washington, Seattle, WA 98195, USA. Electronic address: sheela.sathyanarayana@seattlechildrens.org., Kavanagh TJ; Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98195, USA. Electronic address: tjkav@uw.edu., Krenz JE; Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98195, USA. Electronic address: jkrenz@uw.edu., Andra SS; Department of Environmental Medicine & Public Health, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address: syam.andra@mssm.edu., Kim-Schulze S; Department of Environmental Medicine & Public Health, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address: seunghee.kim-schulze@mssm.edu., Jansen KL; Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98195, USA. Electronic address: kjansen@uw.edu., Torres E; Northwest Communities Education Center, Radio KDNA, Granger, WA 98932, USA. Electronic address: etorres@kdna.org., Perez A; Yakima Valley Farm Workers Clinic, Toppenish, WA 98901, USA. Electronic address: adrianape@yvfwc.org., Younglove LR; Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98195, USA. Electronic address: lry@uw.edu., Tchong-French MI; Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98195, USA. Electronic address: mitchong@uw.edu., Karr CJ; Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98195, USA; Department of Pediatrics, University of Washington, Seattle, WA 98195, USA. Electronic address: ckarr@uw.edu.
Jazyk: angličtina
Zdroj: The Science of the total environment [Sci Total Environ] 2022 Nov 20; Vol. 848, pp. 157493. Date of Electronic Publication: 2022 Jul 22.
DOI: 10.1016/j.scitotenv.2022.157493
Abstrakt: Phthalate exposure is widespread, and studies suggest an adverse relationship with asthma morbidity, including some support for oxidative stress as an underlying pathophysiological mechanism. Urinary phthalate metabolites have been associated with biomarkers of oxidative stress, but data are few in children diagnosed with asthma. We used participant data from the Home Air in Agriculture Pediatric Intervention Trial (HAPI) to examine longitudinal relationships between phthalates and oxidative stress in a cohort of Latino children with asthma residing in an agricultural community. We used linear mixed-effects models to estimate associations between 11 urinary phthalate metabolites (and one summed measure of di-2-ethylhexyl phthalate (DEHP) metabolites, ∑DEHP) and two urinary biomarkers of oxidative stress: a biomarker of lipid peroxidation via measure of 8-isoprostane and a biomarker of DNA/RNA oxidative damage via combined measure of 8-hydroxydeoxyguanosine (8-OHdG), 8-hydroxyguanosine (8-OHG), and 8-hydroxyguanine. Seventy-nine participants provided 281 observations. In covariate-adjusted models, we observed significant positive relationships between all phthalate metabolites and 8-isoprostane, effect sizes ranging from a 9.3 % (95 % CI: 4.2 %-14.7 %) increase in 8-isoprostane for each 100 % increase (i.e., doubling) of mono-(carboxy-isooctyl) phthalate (MCIOP), to a 21.0 % (95 % CI: 14.3 %-28.2 %) increase in 8-isoprostane for each doubling of mono-n-butyl phthalate (MNBP). For each doubling of mono-(carboxy-isononyl) phthalate (MCINP) and mono-ethyl phthalate (MEP), the DNA/RNA oxidative damage biomarker increased by 6.0 % (95 % CI: 0.2 %-12.2 %) and 6.5 % (95 % CI: 1.4 %-11.9 %), respectively. In conclusion, we provide unique data suggesting phthalate exposure is positively associated with oxidative stress in children with asthma. Our repeat measures provide novel identification of a consistent effect of phthalates on oxidative stress in children with asthma via lipid peroxidation. Confirmation in future studies of children with asthma is needed to enhance understanding of the role of phthalates in childhood asthma morbidity.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2022 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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