Case study: Malakoplakia of the bladder.

Autor: Chaudhry N; Department of Pathology, The Ohio State University Wexner Medical Center, James Cancer Hospital and Richard Solove Research Institute, Columbus, OH USA., Vazzano J; Department of Pathology, The Ohio State University Wexner Medical Center, James Cancer Hospital and Richard Solove Research Institute, Columbus, OH USA., Parwani A; Department of Pathology, The Ohio State University Wexner Medical Center, James Cancer Hospital and Richard Solove Research Institute, Columbus, OH USA. Electronic address: anil.parwani@osumc.edu.
Jazyk: angličtina
Zdroj: Pathology, research and practice [Pathol Res Pract] 2022 Sep; Vol. 237, pp. 153852. Date of Electronic Publication: 2022 Mar 28.
DOI: 10.1016/j.prp.2022.153852
Abstrakt: Objectives: Malakoplakia is a rare chronic inflammatory disease thought to be the result of defective bacterial phagocytosis and lysosome function, and there is difficulty in accurate diagnosis as a result of non-specific symptoms that mimic other diseases and cancers. This study presents a case of bladder malakoplakia associated with renal failure presenting as a tumor.
Methods: A 55-year-old woman with history of kidney disease who presented with general malaise and worsening renal failure was found to have a bladder mass and underwent transurethral resection of bladder tumor (TURBT), and subsequent histological examination.
Results: The bladder mass consisted of basophilic structures known as Michaelis-Gutmann bodies within clusters of macrophages on histological examination, and stained positive for CD68. Von Kossa stain highlights Michaelis-Gutmann bodies, consistent with the diagnosis of malakoplakia.
Conclusions: Conservative treatment via antibiotics has been effective. Proper diagnosis of bladder malakoplakia is important, as the conditions it mimics often require surgery and resection. Additionally, it is important to recognize the implications bladder malakoplakia has on renal functioning, particularly regarding urinary obstruction.
(Copyright © 2022. Published by Elsevier GmbH.)
Databáze: MEDLINE
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