In Vivo Evaluation of Permeable and Impermeable Membranes for Guided Bone Regeneration.

Autor: Sartoretto SC; Oral Surgery Department, Dentistry School, Fluminense Federal University, Niteroi 24020-140, Rio de Janeiro, Brazil.; Laboratory for Clinical Research in Dentistry, Dentistry School, Fluminense Federal University, Niteroi 24020-140, Rio de Janeiro, Brazil., Gens NF; Graduate Program, Dentistry School, Fluminense Federal University, Niteroi 24020-140, Rio de Janeiro, Brazil., de Brito Resende RF; Oral Surgery Department, Dentistry School, Fluminense Federal University, Niteroi 24020-140, Rio de Janeiro, Brazil.; Laboratory for Clinical Research in Dentistry, Dentistry School, Fluminense Federal University, Niteroi 24020-140, Rio de Janeiro, Brazil.; Oral Surgery Department, Dentistry School, Iguaçu University, Nova Iguaçu 26275-580, Rio de Janeiro, Brazil., Alves ATNN; Laboratory for Clinical Research in Dentistry, Dentistry School, Fluminense Federal University, Niteroi 24020-140, Rio de Janeiro, Brazil.; Oral Diagnosis Department, Dentistry School, Fluminense Federal University, Niteroi 24020-140, Rio de Janeiro, Brazil., Cecato RC; Implant Dentistry Center for Education and Research on Dental Implants (CEPID), Department of Dentistry, Federal University of Santa Catarina (UFSC), Florianópolis 88000-000, Santa Catarina, Brazil., Uzeda MJ; Oral Surgery Department, Dentistry School, Fluminense Federal University, Niteroi 24020-140, Rio de Janeiro, Brazil.; Laboratory for Clinical Research in Dentistry, Dentistry School, Fluminense Federal University, Niteroi 24020-140, Rio de Janeiro, Brazil.; Oral Surgery Department, Dentistry School, Iguaçu University, Nova Iguaçu 26275-580, Rio de Janeiro, Brazil., Granjeiro JM; Laboratory for Clinical Research in Dentistry, Dentistry School, Fluminense Federal University, Niteroi 24020-140, Rio de Janeiro, Brazil.; National Institute of Metrology, Quality and Technology (INMETRO), Duque de Caxias 25000-000, Rio de Janeiro, Brazil., Calasans-Maia MD; Laboratory for Clinical Research in Dentistry, Dentistry School, Fluminense Federal University, Niteroi 24020-140, Rio de Janeiro, Brazil., Calasans-Maia JA; Laboratory for Clinical Research in Dentistry, Dentistry School, Fluminense Federal University, Niteroi 24020-140, Rio de Janeiro, Brazil.; Orthodontic Department, Dentistry School, Fluminense Federal University, Niteroi 24020-140, Rio de Janeiro, Brazil.
Jazyk: angličtina
Zdroj: Membranes [Membranes (Basel)] 2022 Jul 15; Vol. 12 (7). Date of Electronic Publication: 2022 Jul 15.
DOI: 10.3390/membranes12070711
Abstrakt: Background: The degree of biodegradation and the inflammatory response of membranes employed for guided bone regeneration directly impact the outcome of this technique. This study aimed to evaluate four different experimental versions of Poly (L-lactate-co-Trimethylene Carbonate) (PTMC) + Poly (L-lactate-co-glycolate) (PLGA) membranes, implanted in mouse subcutaneous tissue, compared to a commercially available membrane and a Sham group.
Methods: Sixty Balb-C mice were randomly divided into six experimental groups and subdivided into 1, 3, 6 and 12 weeks (n = 5 groups/period). The membranes (1 cm 2 ) were implanted in the subcutaneous back tissue of the animals. The samples were obtained for descriptive and semiquantitative histological evaluation (ISO 10993-6).
Results: G1 and G4 allowed tissue adhesion and the permeation of inflammatory cells over time and showed greater phagocytic activity and permeability. G2 and G3 detached from the tissue in one and three weeks; however, in the more extended periods, they presented a rectilinear and homogeneous aspect and were not absorbed. G2 had a major inflammatory reaction. G5 was almost completely absorbed after 12 weeks.
Conclusions: The membranes are considered biocompatible. G5 showed a higher degree of biosorption, followed by G1 and G4. G2 and G3 are considered non-absorbable in the studied periods.
Databáze: MEDLINE
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