Photo-excitable zinc sulfide nanoparticles: A theranostic nanotool for cancer management.

Autor: Essawy MM; Department of Oral Pathology, Faculty of Dentistry, Alexandria University, Alexandria, Egypt.; Center of Excellence for Research in Regenerative Medicine and Applications (CERRMA), Faculty of Medicine, Alexandria University, Alexandria, Egypt., Rafik ST; Department of Clinical Pharmacology, Faculty of Medicine, Alexandria University, Alexandria, Egypt., Awaad AK; Center of Excellence for Research in Regenerative Medicine and Applications (CERRMA), Faculty of Medicine, Alexandria University, Alexandria, Egypt.; Department of Biochemistry, Medical Research Institute, Alexandria University, Alexandria, Egypt., Mourad GM; Center of Excellence for Research in Regenerative Medicine and Applications (CERRMA), Faculty of Medicine, Alexandria University, Alexandria, Egypt.; Department of Histology and Cell Biology, Faculty of Medicine, Alexandria University, Alexandria, Egypt., El Achy SN; Center of Excellence for Research in Regenerative Medicine and Applications (CERRMA), Faculty of Medicine, Alexandria University, Alexandria, Egypt.; Department of Pathology, Executive Manager of the Nanomedicine Laboratory at the Center of Excellence for Research in Regenerative Medicine (CERRMA), Faculty of Medicine, Alexandria University, Alexandria, Egypt.
Jazyk: angličtina
Zdroj: Oral diseases [Oral Dis] 2023 Nov; Vol. 29 (8), pp. 3243-3258. Date of Electronic Publication: 2022 Aug 05.
DOI: 10.1111/odi.14324
Abstrakt: Objectives: Zinc sulfide nanoparticles (ZnS NPs), as one of the quantum dots less than 10 nm, possess unique size-dependent autofluorescence. Excitation of their valence electrons by energy higher than the bandgap reveals the ZnS NPs' inherited photocatalysis with additive cytotoxic consequences of reactive oxygen species (ROS) release. Coupling the cytotoxicity of photoactivated ZnS NPs with their autofluorescence would be a novel theranostic modality, combating superficially accessible carcinoma.
Material and Methods: After synthesizing and characterization of ZnS NPs, we verified their photocatalysis and electron donation upon UV excitation in degrading organic dye and DNA cleavage, respectively. We then tested the efficacy of UV-activated ZnS NPs to induce ROS-dependent apoptosis in squamous cell carcinoma and breast cancer cell lines.
Results: The energetic electron-hole pairs generated upon UV excitation of ZnS NPs with the consequent cascade of ROS release revealed potent apoptotic cancer cell deaths, compared with single treatment modalities of nonexcited nanoparticles and UV. Moreover, the inherited luminescence of ZnS NPs enabled visualization of their predominant intracytoplasmic uptake with tracking of their cellular response.
Conclusion: The intensified luminescence and the fortified cytotoxicity of photoactivated ZnS NPs enhance their theranostic qualifications, boosting their antitumorigenic use.
(© 2022 Wiley Periodicals LLC.)
Databáze: MEDLINE
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