| Autor: |
da Silva Canielles Caprara C; Laboratório de Desenvolvimento de Novos Fármacos, Faculdade de Medicina, Universidade Federal do Rio Grande (FURG) - Rio Grande, Rio Grande, Brazil., da Silva Freitas L; Laboratório de Desenvolvimento de Novos Fármacos, Faculdade de Medicina, Universidade Federal do Rio Grande (FURG) - Rio Grande, Rio Grande, Brazil., Iglesias BA; Departamento de Química, Laboratório de Bioinorgânica e Materiais Porfirínicos, Universidade Federal de Santa Maria, Santa Maria, Brazil., Ferreira LB; Laboratório de Desenvolvimento de Novos Fármacos, Faculdade de Medicina, Universidade Federal do Rio Grande (FURG) - Rio Grande, Rio Grande, Brazil., Ramos DF; Laboratório de Desenvolvimento de Novos Fármacos, Faculdade de Medicina, Universidade Federal do Rio Grande (FURG) - Rio Grande, Rio Grande, Brazil. |
| Abstrakt: |
In the last decade , Acinetobacter baumannii has emerged as a pathogen associated with infections in intensive care units worldwide, especially due to its ability to resist an extensive list of antibiotics. In this context, porphyrins have emerged as an important strategy in photodynamic therapy, since they are a group of tetrapyrrolic compounds with important photochemical and photobiological activities. In this study, the antimicrobial photodynamic activity of meso -tetra(4- N-methyl -pyridyl)porphyrin ( H 2 TMePyP + ) and meso -tetra(4-sulfonatophenyl)porphyrin ( H 2 TPPS ‒ ) was evaluated against A. baumannii by minimum inhibitory concentration (MIC), anti-biofilm activity, and the interaction with antibiotics after exposure to white-light LED irradiation. The cationic derivative H 2 TMePyP + was more potent (MIC = 0.61 µM) than H 2 TPPS ‒ , with anti-biofilm activity and increased the antimicrobial activity of ciprofloxacin and amikacin. Given these findings, the tetra-cationic porphyrins can be assumed as prototypes to optimize and develop new agents by promoting oxidative stress and inducing free radical production. |
