| Autor: |
Hou M; School of Chemistry and Chemical Engineering, Chongqing University, 174 Shazheng Street, Chongqing 400044, P. R. China., Ye M; Institute for Clean Energy and Advanced Materials, School of Materials and Energy, Southwest University, Chongqing 400715, P. R. China., Liu L; School of Chemistry and Chemical Engineering, Chongqing University, 174 Shazheng Street, Chongqing 400044, P. R. China., Xu M; School of Chemistry and Chemical Engineering, Chongqing University, 174 Shazheng Street, Chongqing 400044, P. R. China., Liu H; Institute for Clean Energy and Advanced Materials, School of Materials and Energy, Southwest University, Chongqing 400715, P. R. China., Zhang H; Institute for Clean Energy and Advanced Materials, School of Materials and Energy, Southwest University, Chongqing 400715, P. R. China., Li Y; Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, Innovative Drug Research Center, School of Pharmaceutical Sciences, Chongqing University, Chongqing 401331, P. R. China., Xu Z; Institute for Clean Energy and Advanced Materials, School of Materials and Energy, Southwest University, Chongqing 400715, P. R. China., Li B; School of Chemistry and Chemical Engineering, Chongqing University, 174 Shazheng Street, Chongqing 400044, P. R. China. |
| Abstrakt: |
Fabrication of self-delivery drug systems can surmount low drug bioavailability and achieve a precise therapeutic process. In this study, a hydrogen sulfide-responsive (H 2 S) small molecule prodrug was synthesized by linking two chemotherapy drugs, camptothecin (CPT) and gemcitabine (GT), using a reductive disulfide bond simultaneously with a lock GT strategy using a H 2 S-responsive azide group (denoted as N 3 -GT-CPT). The ingenious design endows the easy coprecipitation peculiarity of the prodrug with clinical indocyanine green (ICG) via a combined interaction force of hydrophobic, π-π stacking, and electrostatic interactions of anions and cations, thus producing a more stable and multifunctional therapeutic nanosystem. Considering the great photothermal and imaging ability of ICG, the obtained nanosystem showed an excellent therapeutic ability against colon tumors in vitro and in vivo with selective response to intercellular H 2 S, thus offering a good combination-based multiple therapy for treatment of tumors. |
