Evaluation of Metal-Organic Framework MIL-89 nanoparticles toxicity on embryonic zebrafish development.

Autor:	Al-Ansari DE; Biological Science Program, Department of Biological and Environmental Sciences, College of Arts and Sciences, Qatar University, Doha, Qatar.; Division of Biological and Biomedical Sciences, College of Health and Life Sciences, Hamad Bin Khalifa University, Qatar Foundation, Doha, Qatar., Al-Badr M; Biological Science Program, Department of Biological and Environmental Sciences, College of Arts and Sciences, Qatar University, Doha, Qatar.; Biomedical Research Center, Qatar University, Doha, Qatar., Zakaria ZZ; Biological Science Program, Department of Biological and Environmental Sciences, College of Arts and Sciences, Qatar University, Doha, Qatar.; Biomedical Research Center, Qatar University, Doha, Qatar., Mohamed NA; Biomedical Research Center, Qatar University, Doha, Qatar., Nasrallah GK; Biomedical Research Center, Qatar University, Doha, Qatar.; College of Health Sciences, Department of Biomedical Sciences, Qatar University, Doha, Qatar., Yalcin HC; Biomedical Research Center, Qatar University, Doha, Qatar., Abou-Saleh H; Biological Science Program, Department of Biological and Environmental Sciences, College of Arts and Sciences, Qatar University, Doha, Qatar.; Biomedical Research Center, Qatar University, Doha, Qatar.
Jazyk:	angličtina
Zdroj:	Toxicology reports [Toxicol Rep] 2022 Apr 20; Vol. 9, pp. 951-960. Date of Electronic Publication: 2022 Apr 20 (Print Publication: 2022).
DOI:	10.1016/j.toxrep.2022.04.016
Abstrakt:	Metal-Organic Framework MIL-89 nanoparticles garnered remarkable attention for their widespread use in technological applications. However, the impact of these nanomaterials on human and environmental health is still limited, and concerns regarding the potential risk of exposure during manipulation is constantly rising. Therefore, the extensive use of nanomaterials in the medical field necessitates a comprehensive assessment of their safety and interaction with different tissues of the body system. In this study, we evaluated the systemic toxicity of nanoMIL-89 using Zebrafish embryos as a model system to determine the acute developmental effect. Zebrafish embryos were exposed to a range of nanoMIL-89 concentrations (1 - 300 µM) at 4 h post-fertilization (hpf) for up to 120 hpf. The viability and hatching rate were evaluated at 24-72 hpf, whereas the cardiac function was assessed at 72 and 96 hpf, and the neurodevelopment and hepatic steatosis at 120 hpf. Our study shows that nanoMIL-89 exerted no developmental toxicity on zebrafish embryos at low concentrations (1-10 µM). However, the hatching time and heart development were affected at high concentrations of nanoMIL-89 (> 30 µM ). Our findings add novel information into the available data about the in vivo toxicity of nanoMIL-89 and demonstrate its innocuity and safe use in biological, environmental, and medical applications. Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (© 2022 The Authors.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu