Fever of Unknown Origin, Wasting Syndrome and Bone Marrow Involvement: A Leprosy Case Report.
Autor: | Santana MAO; National Reference Center for Sanitary Dermatology and Leprosy, Clinics' Hospital, Faculty of Medicine, Federal University of Uberlândia, Uberlândia, Brazil., da Costa WVT; Faculty of Medicine, Federal University of Uberlândia, Uberlândia, Brazil., Celestino IC; Post-Graduation Program in Health Science, Faculty of Medicine, Federal University of Uberlândia, Uberlândia, Brazil., Dos Santos DF; National Reference Center for Sanitary Dermatology and Leprosy, Clinics' Hospital, Faculty of Medicine, Federal University of Uberlândia, Uberlândia, Brazil.; Faculty of Medicine, Federal University of Uberlândia, Uberlândia, Brazil., Dornelas BC; Post-Graduation Program in Health Science, Faculty of Medicine, Federal University of Uberlândia, Uberlândia, Brazil.; Pathology Department, Clinical Hospital, Faculty of Medicine, Federal University of Uberlândia, Uberlândia, Brazil., Pavelka MM; School of Medicine, Indiana University, Terre Haute, IN, United States., Luppi AM; National Reference Center for Sanitary Dermatology and Leprosy, Clinics' Hospital, Faculty of Medicine, Federal University of Uberlândia, Uberlândia, Brazil.; Post-Graduation Program in Health Science, Faculty of Medicine, Federal University of Uberlândia, Uberlândia, Brazil., Goulart IMB; National Reference Center for Sanitary Dermatology and Leprosy, Clinics' Hospital, Faculty of Medicine, Federal University of Uberlândia, Uberlândia, Brazil.; Faculty of Medicine, Federal University of Uberlândia, Uberlândia, Brazil. |
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Jazyk: | angličtina |
Zdroj: | Frontiers in immunology [Front Immunol] 2022 Jul 07; Vol. 13, pp. 916319. Date of Electronic Publication: 2022 Jul 07 (Print Publication: 2022). |
DOI: | 10.3389/fimmu.2022.916319 |
Abstrakt: | Mycobacterium leprae , the etiologic agent of leprosy, is an acid-fast-staining and slow-growing bacilli that infect macrophages and Schwann cells individually or through forming globi. The clinical presentation of leprosy is broad and depends on the host immune response. We report a case of a 42-year-old Brazilian man presenting with fever of unknown origin (FUO), anemia, wasting syndrome, and neuropathy. The diagnosis of lepromatous leprosy was made after an extensive investigation revealed the presence of M. leprae in the bone marrow. Bone marrow involvement in leprosy is rare and some authors believe the presence of M. leprae in the bone marrow can act as a reservoir of the disease facilitating future relapses. It is important to investigate bone marrow involvement in leprosy, especially when the patient presents with cytopenias and positive epidemiologic history. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Santana, da Costa, Celestino, dos Santos, Dornelas, Pavelka, Luppi and Goulart.) |
Databáze: | MEDLINE |
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