Parathyroid Carcinoma All-In-One, a Rare Life-Threatening Case With Multiple Systemic Manifestations: Case Report and Review of the Literature.

Autor:	Zelano L; Department of Translational Medicine and Surgery, Unit of Endocrinology, Università Cattolica del Sacro Cuore-Fondazione Policlinico 'Gemelli' IRCCS, Rome, Italy., Locantore P; Department of Translational Medicine and Surgery, Unit of Endocrinology, Università Cattolica del Sacro Cuore-Fondazione Policlinico 'Gemelli' IRCCS, Rome, Italy., Rota CA; Department of Translational Medicine and Surgery, Unit of Endocrinology, Università Cattolica del Sacro Cuore-Fondazione Policlinico 'Gemelli' IRCCS, Rome, Italy., Policola C; Department of Translational Medicine and Surgery, Unit of Endocrinology, Università Cattolica del Sacro Cuore-Fondazione Policlinico 'Gemelli' IRCCS, Rome, Italy., Corsello A; Department of Translational Medicine and Surgery, Unit of Endocrinology, Università Cattolica del Sacro Cuore-Fondazione Policlinico 'Gemelli' IRCCS, Rome, Italy., Rossi ED; Institute of Pathology, Università Cattolica del Sacro Cuore-Fondazione Policlinico 'Gemelli' IRCCS, Rome, Italy., Rufini V; Institute of Nuclear Medicine, Università Cattolica del Sacro Cuore-Fondazione Policlinico 'Gemelli' IRCCS, Rome, Italy., Zagaria L; Institute of Nuclear Medicine, Università Cattolica del Sacro Cuore-Fondazione Policlinico 'Gemelli' IRCCS, Rome, Italy., Raffaelli M; Department of Endocrine and Metabolic Surgery, Università Cattolica del Sacro Cuore-Fondazione Policlinico 'Gemelli' IRCCS, Rome, Italy., Pontecorvi A; Department of Translational Medicine and Surgery, Unit of Endocrinology, Università Cattolica del Sacro Cuore-Fondazione Policlinico 'Gemelli' IRCCS, Rome, Italy.
Jazyk:	angličtina
Zdroj:	Frontiers in endocrinology [Front Endocrinol (Lausanne)] 2022 Jul 07; Vol. 13, pp. 881225. Date of Electronic Publication: 2022 Jul 07 (Print Publication: 2022).
DOI:	10.3389/fendo.2022.881225
Abstrakt:	Parathyroid carcinoma (PC) is an extremely rare disease. Although it may occasionally occur in genetic syndromes, it is more often sporadic. It is usually associated with a consistent secretion of PTH, causing severe hypercalcemia and potentially all clinical conditions due to primary hyperparathyroidism. Management of PC can be challenging: some clinical, biochemical, and radiological features may be useful, but the final diagnosis of malignancy strictly relies on histological criteria. To date, radical surgery is the first-choice treatment and is the only effective therapy to control hypercalcemia and other clinical manifestations. On the other hand, chemo- or radiotherapy, local treatments, or novel drugs should be reserved for selected cases. We report an exceptionally unusual case of life-threatening PC, associated with several systemic manifestations: moderate pancreatitis, portal thrombosis, kidney stones, brown tumors, osteoporosis, hungry bone syndrome (HBS), chondrocalcinosis, neuropathy, and depression. The clinical case also represents an opportunity to provide a review of the recent literature, associated with a complete evaluation of the main diagnostic and therapeutic approaches. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Zelano, Locantore, Rota, Policola, Corsello, Rossi, Rufini, Zagaria, Raffaelli and Pontecorvi.)
Databáze:	MEDLINE
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