Cognitive function and vitamin B12 and D among community-dwelling elders: A cross-sectional study.

Autor: Vinueza Veloz AF; Department of Neurology, Hermanos Ameijeiras Hospital, La Habana, Cuba., Carpio Arias TV; GIANH, School of Nutrition and Dietetics, Public Health Faculty, Escuela Superior Politécnica de Chimborazo, Riobamba, Ecuador., Vargas Mejía JS; Gamma Salud Hospital, Guaranda, Ecuador., Tapia Veloz EC; Department of Pharmacy and Pharmaceutical Technology and Parasitology, University of Valencia, Valencia, Spain., Piedra Andrade JS; Department of Neurology, Carlos Andrade Marín Hospital, Quito, Ecuador., Nicolalde Cifuentes TM; School of Medicine, Public Health Faculty, Escuela Superior Politécnica de Chimborazo, Riobamba, Ecuador., Heredia Aguirre SI; School of Nutrition and Dietetics, Public Health Faculty, Escuela Superior Politécnica de Chimborazo, Riobamba, Ecuador., Vinueza Veloz MF; Department of Community Medicine and Global Health, University of Oslo, Oslo, Norway; Department of Neuroscience, Erasmus MC, Rotterdam, the Netherlands. Electronic address: m.f.v.veloz@medisin.uio.no.
Jazyk: angličtina
Zdroj: Clinical nutrition ESPEN [Clin Nutr ESPEN] 2022 Aug; Vol. 50, pp. 270-276. Date of Electronic Publication: 2022 May 23.
DOI: 10.1016/j.clnesp.2022.05.004
Abstrakt: Background & Aims: Little is know on the association between mild or sub-clinical vitamin B12 or D deficiencies and cognitive decline. The objective of the present work was to evaluate the association between vitamin B12 and D levels, and cognitive function in community-dwelling elders.
Methods: Cross-sectional study that included data from elders who participated in the SABE study, a population-based study that was carried out in Ecuador. Participants of SABE were selected by probabilistic sampling from the whole country. Vitamin B12 and D were measured in blood and cognitive status was assessed using an abbreviated version of the minimental state examination (MMSE).
Results: The sample included 1733 elders from whom 936 (54.01%) were female. Independently from sex, age, years of education, ethnicity, socioeconomic status and geographical zone of residence, we found that vitamin B12 levels were associated to MMSE scores and that this relationship changed depending on age. In this way, we observed that from 75 years of age, drop of cognitive function was particularly steep in individuals with low levels of vitamin B12. We did not find evidence to support an association between vitamin D levels and cognitive function.
Conclusions: Low levels of vitamin B12 but not of vitamin D are associated with low cognitive functioning in a sample of community-dwelling elders.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2022 The Author(s). Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: