Handgrip strength to screen early-onset sarcopenia in heart failure.

Autor: Blanquet M; Department of Medicine, Mauriac Hospital Centre, 15200 Mauriac, France; Department of Public Health, Clermont-Ferrand University Hospital, Clermont-Ferrand, France; Université Clermont Auvergne, Clermont-Ferrand University Hospital, CNRS, SIGMA Clermont, Institut Pascal, 63000 Clermont-Ferrand, France. Electronic address: mblanquet@chu-clermontferrand.fr., Massoulié G; Department of Cardiology, Clermont-Ferrand University Hospital, France., Boirie Y; Clinical Nutrition Department, Clermont-Ferrand University Hospital, France; Université Clermont Auvergne, Nutritional Health Unit, INRAE, CRNH Auvergne, 63000, Clermont-Ferrand, France., Guiguet-Auclair C; Department of Public Health, Clermont-Ferrand University Hospital, Clermont-Ferrand, France; Université Clermont Auvergne, Clermont-Ferrand University Hospital, CNRS, SIGMA Clermont, Institut Pascal, 63000 Clermont-Ferrand, France., Mulliez A; Biostatistics Unit (Clinical Research and Innovation Division), Clermont-Ferrand University Hospital, Clermont-Ferrand, France., Anker S; Department of Cardiology (CVK), Berlin Institute of Health Center for Regenerative Therapies (BCRT), German Centre for Cardiovascular Research 5dzhk° Partner Site Berlin, Charité Universitätsmedizin Berlin, Germany., Boiteux MD; Durtol, Cardiac Rehabilitation Centre, Durtol, France., Jean F; Department of Cardiology, Clermont-Ferrand University Hospital, France., Combaret N; Department of Cardiology, Clermont-Ferrand University Hospital, France., Souteyrand G; Department of Cardiology, Clermont-Ferrand University Hospital, France., Riocreux C; Department of Cardiology, Clermont-Ferrand University Hospital, France., Pereira B; Biostatistics Unit (Clinical Research and Innovation Division), Clermont-Ferrand University Hospital, Clermont-Ferrand, France., Motreff P; Department of Cardiology, Clermont-Ferrand University Hospital, France., Rossignol P; Lorraine Université, France; INSERM, Clinical Investigation Centre CIC-P 1433, Nancy Regiona University Hospital, 54000, Nancy, France; INSERM U1116, Nancy, France; F-CRIN, INI-CRCT, Nancy, France., Clerfond G; Department of Cardiology, Clermont-Ferrand University Hospital, France., Eschalier R; Université Clermont Auvergne, Clermont-Ferrand University Hospital, CNRS, SIGMA Clermont, Institut Pascal, 63000 Clermont-Ferrand, France; Department of Cardiology, Clermont-Ferrand University Hospital, France; INSERM U1116, Nancy, France.
Jazyk: angličtina
Zdroj: Clinical nutrition ESPEN [Clin Nutr ESPEN] 2022 Aug; Vol. 50, pp. 183-190. Date of Electronic Publication: 2022 Jun 06.
DOI: 10.1016/j.clnesp.2022.05.019
Abstrakt: Background & Aims: Sarcopenia in heart failure (HF) is associated with severe outcomes, increased mortality, and high healthcare cost burden. Systematic muscle screening in patients with chronic HF would improve quality and appropriateness of care. Here we tested handgrip strength (HGS) as a screening tool for sarcopenia in patients with chronic HF, using the EWGSOP 2010 and 2019 reference-standard definitions of sarcopenia.
Methods: HF inpatients, aged 65 years old or above, were prospectively included between November 2014 and September 2018, and relevant sociodemographic, anthropometric and HF characterization data was collected. The accuracy of HGS as a screening test for sarcopenia was assessed by gender using area under the receiver operating characteristic (ROC) curves (AUC).
Results: The population consisted of 118 older patients (age: 78.9 yrs; BMI: 26.6 kg/m 2 ) with a mean HGS of 16.1 kg (SD 4.6) in women and 26.5 kg (SD 6.7) in men. Factors associated with HGS were age (p = 0.005), Instrumental Activity of Daily Living (p = 0.001), and heart rate (p = 0.034). Screening was positive (patients confirmed as sarcopenic by the HGS test) with cut-off values of 18 kg for women and 27 kg for men, with ROC analysis giving a sensitivity of 85.7% in women and 88.2% in men.
Conclusions: HGS can be used as a valid tool to screen for sarcopenia in older (≥65 yrs) patients with chronic HF.
Clinical Trial Registration: NCT03153774.
Competing Interests: Declaration of competing interest The authors have no conflicts of interest.
(Copyright © 2022 European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: