Skin-patch delivered subunit vaccine induces broadly neutralising antibodies against SARS-CoV-2 variants of concern.

Autor: McMillan CLD; School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, Queensland, Australia., Amarilla AA; School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, Queensland, Australia., Modhiran N; School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, Queensland, Australia., Choo JJY; School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, Queensland, Australia., Azuar A; School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, Queensland, Australia., Honeyman KE; School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, Queensland, Australia., Khromykh AA; School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, Queensland, Australia., Young PR; School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, Queensland, Australia; Australian Infectious Diseases Research Centre, Global Virus Network Centre of Excellence, Brisbane, Queensland, Australia., Watterson D; School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, Queensland, Australia; Australian Infectious Diseases Research Centre, Global Virus Network Centre of Excellence, Brisbane, Queensland, Australia., Muller DA; School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, Queensland, Australia; Australian Infectious Diseases Research Centre, Global Virus Network Centre of Excellence, Brisbane, Queensland, Australia. Electronic address: d.muller4@uq.edu.au.
Jazyk: angličtina
Zdroj: Vaccine [Vaccine] 2022 Aug 12; Vol. 40 (34), pp. 4929-4932. Date of Electronic Publication: 2022 Jul 18.
DOI: 10.1016/j.vaccine.2022.07.013
Abstrakt: The ongoing SARS-CoV-2 pandemic continues to pose an enormous health challenge globally. The ongoing emergence of variants of concern has resulted in decreased vaccine efficacy necessitating booster immunizations. This was particularly highlighted by the recent emergence of the Omicron variant, which contains over 30 mutations in the spike protein and quickly became the dominant viral strain in global circulation. We previously demonstrated that delivery of a SARS-CoV-2 subunit vaccine via a high-density microarray patch (HD-MAP) induced potent immunity resulting in robust protection from SARS-CoV-2 challenge in mice. Here we show that serum from HD-MAP immunized animals maintained potent neutralisation against all variants tested, including Delta and Omicron. These findings highlight the advantages of HD-MAP vaccine delivery in inducing high levels of neutralising antibodies and demonstrates its potential at providing protection from emerging viral variants.
Competing Interests: Declaration of Competing Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: David Muller reports financial support was provided by Vaxxas Pty Ltd. David Muller reports a relationship with Vaxxas that includes: consulting or advisory and funding grants. Paul Young reports a relationship with Vaxxas that includes: consulting or advisory.
(Copyright © 2022. Published by Elsevier Ltd.)
Databáze: MEDLINE
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