Associations Between Vascular Risk Factors and Perivascular Spaces in Adults with Intact Cognition, Mild Cognitive Impairment, and Dementia.

Autor:	Rundek T; The Evelyn F. McKnight Brain Institute, University of Miami Miller School of Medicine, Miami, FL, USA.; Department of Neurology, University of Miami Miller School of Medicine, Miami, FL, USA., Del Brutto VJ; Department of Neurology, University of Miami Miller School of Medicine, Miami, FL, USA., Goryawala M; The Evelyn F. McKnight Brain Institute, University of Miami Miller School of Medicine, Miami, FL, USA.; Department of Radiology, University of Miami Miller School of Medicine, Miami, FL, USA., Dong C; The Evelyn F. McKnight Brain Institute, University of Miami Miller School of Medicine, Miami, FL, USA.; Department of Neurology, University of Miami Miller School of Medicine, Miami, FL, USA., Agudelo C; The Evelyn F. McKnight Brain Institute, University of Miami Miller School of Medicine, Miami, FL, USA.; Department of Neurology, University of Miami Miller School of Medicine, Miami, FL, USA., Saporta AS; The Evelyn F. McKnight Brain Institute, University of Miami Miller School of Medicine, Miami, FL, USA.; Department of Neurology, University of Miami Miller School of Medicine, Miami, FL, USA., Merritt S; The Evelyn F. McKnight Brain Institute, University of Miami Miller School of Medicine, Miami, FL, USA.; Department of Neurology, University of Miami Miller School of Medicine, Miami, FL, USA., Camargo C; The Evelyn F. McKnight Brain Institute, University of Miami Miller School of Medicine, Miami, FL, USA.; Department of Neurology, University of Miami Miller School of Medicine, Miami, FL, USA., Ariko T; The Evelyn F. McKnight Brain Institute, University of Miami Miller School of Medicine, Miami, FL, USA., Loewenstein DA; The Evelyn F. McKnight Brain Institute, University of Miami Miller School of Medicine, Miami, FL, USA.; The Center for Neurocognitive Sciences and Aging, University of Miami Miller School of Medicine, Miami, FL, USA.; Department of Psychiatry, University of Miami Miller School of Medicine, Miami, FL, USA., Duara R; Wien Center for Alzheimer's Disease and Memory Disorders, Mount Sinai Medical Center, Miami Beach, FL, USA., Haq I; The Evelyn F. McKnight Brain Institute, University of Miami Miller School of Medicine, Miami, FL, USA.; Department of Neurology, University of Miami Miller School of Medicine, Miami, FL, USA.
Jazyk:	angličtina
Zdroj:	Journal of Alzheimer's disease : JAD [J Alzheimers Dis] 2022; Vol. 89 (2), pp. 437-448.
DOI:	10.3233/JAD-215585
Abstrakt:	Background: Perivascular spaces (PVS) are fluid-filled compartments surrounding small intracerebral vessels that transport fluid and clear waste. Objective: We examined associations between PVS count, vascular and neurodegenerative risk factors, and cognitive status among the predominantly Hispanic participants of the FL-VIP Study of Alzheimer's Disease Risk. Methods: Using brain MRI (n = 228), we counted PVS in single axial image through the basal ganglia (BG) and centrum semiovale (CSO). PVS per region were scored as 0 (none), 1 (<10), 2 (11-20), 3 (21-40), and 4 (>40). Generalized linear models examined PVS associations with vascular risk factors and a composite vascular comorbidity risk (VASCom) score. Results: Our sample (mean age 72±8 years, 61% women, 60% Hispanic, mean education 15±4 years, 33% APOE4 carriers) was 59% hypertensive, 21% diabetic, 66% hypercholesteremic, and 30% obese. Mean VASCom score was 2.3±1.6. PVS scores ranged from 0-4 in the BG (mean 1.3±0.7) and CSO (mean 1.2±0.9), and 0-7 combined (mean 2.5±1.4). In multivariable regression models, BG PVS was associated with age (β= 0.03/year, p < 0.0001), Hispanic ethnicity (β= 0.29, p = 0.01), education (β= 0.04/year, p = 0.04), and coronary bypass surgery (β= 0.93, p = 0.02). CSO PVS only associated with age (β= 0.03/year, p < 0.01). APOE4 and amyloid-β were not associated with PVS. Conclusion: BG PVS may be a marker of subclinical cerebrovascular disease. Further research is needed to validate associations and identify mechanisms linking BG PVS and cerebrovascular disease markers. PVS may be a marker of neurodegeneration despite our negative preliminary findings and more research is warranted. The association between BG PVS and Hispanic ethnicity also requires further investigation.
Databáze:	MEDLINE
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