Retrospective study of histopathological and prognostic characteristics of primary fallopian tube carcinomas: twenty-year experience (SOCRATE).

Autor:	Borghese M; Department of Obstetrics and Gynecology, Azienda Ospedaliera Ordine Mauriziano di Torino, Torino, Piemonte, Italy martina.borghese1989@gmail.com., Vizzielli G; Department of Medical Area (DAME), University of Udine, Clinic of Obstetrics and Gynecology, 'Santa Maria della Misericordia' University Hospital - Azienda Sanitaria Universitaria Friuli Centrale, Udine, Italy., Capelli G; Dipartimento di Scienze Umane, Sociali e della Salute, Università di Cassino e del Lazio Meridionale, Rome, Italy., Santoro A; Dipartimento Scienze della Salute della Donna, del Bambino e di Sanità Pubblica, Unità di Gineco-patologia e Patologia Mammaria, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy., Angelico G; Pathology, Dipartimento Scienze della Salute della Donna, del Bambino e di Sanità Pubblica, Unità di Gineco-patologia e Patologia Mammaria, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168, Rome, Italy, Rome, Italy., Arciuolo D; Dipartimento Scienze della Salute della Donna, del Bambino e di Sanità Pubblica, Unità di Gineco-patologia e Patologia Mammaria, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy., Biglia N; Obstetrics and Gynecology, Azienda Ospedaliera Ordine Mauriziano di Torino, Torino, Piemonte, Italy., Ferrero A; Obstetrics and Gynecology, Azienda Ospedaliera Ordine Mauriziano di Torino, Torino, Piemonte, Italy., Sgro LG; Obstetrics and Gynecology, Azienda Ospedaliera Ordine Mauriziano di Torino, Torino, Piemonte, Italy., Ponzone R; Gynecological Oncology Unit, Candiolo Cancer Institute, FPO - IRCCS, Turin, Italy., Scambia G; Gynecologic Oncology Unit, Women Wealth Area, Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy; Catholic University of Sacred Heart, Roma, Italy., Fagotti A; Gynecologic Oncology Unit, Women Wealth Area, Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy; Catholic University of Sacred Heart, Roma, Italy., Zannoni GF; Dipartimento Scienze della Salute della Donna, del Bambino e di Sanità Pubblica, Unità di Gineco-patologia e Patologia Mammaria, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.; Istituto di Anatomia Patologica, Università Cattolica del Sacro Cuore, Rome, Italy.
Jazyk:	angličtina
Zdroj:	International journal of gynecological cancer : official journal of the International Gynecological Cancer Society [Int J Gynecol Cancer] 2022 Jul 22. Date of Electronic Publication: 2022 Jul 22.
DOI:	10.1136/ijgc-2022-003468
Abstrakt:	Objective: Primary fallopian tube carcinoma represents a rare entity, accounting for about 0.75%-1.2% of all gynecological malignancies. The rationale of our study is to describe the prognosis of primary fallopian tube carcinoma. Methods: We retrospectively identified patients with FIGO stage I-IV, all histology types and grading primary fallopian tube carcinoma treated in three major oncological centers between January 2000 and March 2020. Exclusion criteria were bulky tubo-ovarian carcinomas, isolated serous tubal intraepithelial carcinoma or neoadjuvant chemotherapy. Results: A total of 61 patients were included. The vast majority of primary fallopian tube carcinomas were serous (96.7%) and poorly differentiated (96.7%) and arose from the fimbriated end of the tube (88.5%). Larger tumor size correlated with higher probability of correct preoperative differential diagnosis of primary fallopian tube carcinoma (p=0.003). Up to 82.4% of patients with small tumors (≤15 mm) presented with high FIGO stage (≥IIA). The most common site of metastasis was pelvic peritoneum (18.8%) and among 59% of patients who underwent lymphadenectomy smaller tumors had higher rate of nodal metastasis (42.9%≤10 mm vs 27.3%>50 mm). After 46.0 months of mean follow-up there were 27 recurrences (48.2%). The most common site of relapse was diffuse peritoneal spread (18.5%). The 5-year disease-free survival was 45.2% and 5-year overall survival was 75.5%. Of note, 42.9% of patients with stage IVB survived >36 months. Conclusion: Primary fallopian tube carcinoma is a biologically distinct tumor from primary epithelial ovarian carcinoma and it is mostly located in the fimbriated end of the tube. In addition, it is characterized by a high rate of retroperitoneal dissemination even at apparently an early stage and its size does not correlate with FIGO stage at presentation. Competing Interests: Competing interests: None declared. (© IGCS and ESGO 2022. No commercial re-use. See rights and permissions. Published by BMJ.)
Databáze:	MEDLINE
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